Self‐photocatalyzed Homolytic Dehalogenative Alkylation/Cyclization of Unactivated Alkenes Based on the Quinazolinone Skeleton via Energy Transfer

Self‐photocatalyzed Homolytic Dehalogenative Alkylation/Cyclization of Unactivated Alkenes Based on the Quinazolinone Skeleton via Energy Transfer

A mild, external photocatalyst‐ and additive‐free protocol for photo‐induced alkylation/cyclization of unactivated alkenes with halides has been developed. This strategy showed excellent regioselectivity and simple operation to synthesize alkyl‐substituted quinazolinones with a broad substrate scope...

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Veröffentlicht in:Asian journal of organic chemistry 2021-12, Vol.10 (12), p.3390-3395
Hauptverfasser: Sun, Bin, Tang, Xiaoli, Shi, Rongcheng, Yan, Zhiyang, Li, Bingqian, Tang, Chen, Jin, Can, Wu, Chunlei L., Shen, Runpu P.
Format: Artikel
Sprache:eng
Schlagworte:
Alkanes
Alkenes
Alkylation
Alkylation/cyclization
Energy transfer
Halides
Malonate
Organic chemistry
Quinazolinone
Quinazolinones
Regioselectivity
Self-photocatalyzsis
Substrates
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Zusammenfassung:A mild, external photocatalyst‐ and additive‐free protocol for photo‐induced alkylation/cyclization of unactivated alkenes with halides has been developed. This strategy showed excellent regioselectivity and simple operation to synthesize alkyl‐substituted quinazolinones with a broad substrate scope. More importantly, chlorinated alkanes were also compatible with this transformation. A mild, external photocatalyst and additive‐free protocol for photo‐induced alkylation/cyclization of unactivated alkenes with halides has been developed.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.202100606