Α case of seronegative autoimmune encephalitis associated with human herpesvirus‐7 (HHV‐7)
In the last 10 years, an increased number of patients presenting with acute encephalitis is being observed, a finding that is attributed to autoimmune mechanisms. Despite the fact that autoantibodies usually target the neuronal cell surface or synaptic proteins in the central nervous system (CNS), i...
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| Veröffentlicht in: | Journal of medical virology 2022-02, Vol.94 (2), p.795-798 |
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| container_title | Journal of medical virology |
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| creator | Christou, Evangelos Mastrogianni, Sotiria Bourousis, Evangelos Bachou, Theodora Tsikrikas, Theodoros Mouskou, Stella Voudris, Konstantinos Delis, Dimitrios |
| description | In the last 10 years, an increased number of patients presenting with acute encephalitis is being observed, a finding that is attributed to autoimmune mechanisms. Despite the fact that autoantibodies usually target the neuronal cell surface or synaptic proteins in the central nervous system (CNS), in many cases these remain undetectable, constituting a future diagnostic and therapeutic challenge. Human herpesvirus‐7 (HHV‐7) is proven to be a neurotropic virus, causing various neurological complications mostly in the adult population. We present the case of a 10‐year‐old girl, with confirmed active HHV‐7 infection of the CNS, who developed acute seronegative autoimmune encephalitis. To our best knowledge, there is no literature concerning pediatric cases of autoimmune encephalitis following HHV‐7 infection. |
| doi_str_mv | 10.1002/jmv.27411 |
| format | Article |
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Despite the fact that autoantibodies usually target the neuronal cell surface or synaptic proteins in the central nervous system (CNS), in many cases these remain undetectable, constituting a future diagnostic and therapeutic challenge. Human herpesvirus‐7 (HHV‐7) is proven to be a neurotropic virus, causing various neurological complications mostly in the adult population. We present the case of a 10‐year‐old girl, with confirmed active HHV‐7 infection of the CNS, who developed acute seronegative autoimmune encephalitis. 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To our best knowledge, there is no literature concerning pediatric cases of autoimmune encephalitis following HHV‐7 infection.</description><subject>acute encephalitis</subject><subject>Antibodies, Viral - blood</subject><subject>Autoantibodies</subject><subject>Autoantibodies - cerebrospinal fluid</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases of the Nervous System - cerebrospinal fluid</subject><subject>Brain - pathology</subject><subject>Cell surface</subject><subject>Central nervous system</subject><subject>Child</subject><subject>Complications</subject><subject>Encephalitis</subject><subject>Encephalitis - cerebrospinal fluid</subject><subject>Female</subject><subject>Herpesvirus 7, Human</subject><subject>HHV‐7 infection</subject><subject>Humans</subject><subject>Infections</subject><subject>Magnetic Resonance Imaging</subject><subject>Neurological complications</subject><subject>Pediatrics</subject><subject>Recurrence</subject><subject>Roseolovirus Infections - cerebrospinal fluid</subject><subject>seronegative autoimmune encephalitis</subject><subject>Virology</subject><subject>Viruses</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1O20AURkeoVQm0C14AjdQNLAz3juP5WVYRECoqNpTtaDK-JhPFdpixg9jxCPBiPARPgiHQXVf3Lo7OJx3G9hCOEEAcL-r1kVBjxC02QjAyM6DwCxsBjmUmJRbbbCelBQBoI8Q3tp2PpZJamxGzz0_cu0S8rXii2DZ047qwJu76rg113TfEqfG0mrtl6ELiLqXWB9dRye9CN-fzvnYNn1NcUVqH2KeXh0fFD6bT67fn8Dv7Wrlloh8fd5f9PT25mkyzi8uz88mvi8znAjCrDI1NKakyfqYKUAAlUjHTuXdGGqEKYXRlNJEsYWa0QvClzxGFNoiqkPku-7nxrmJ721Pq7KLtYzNMWiFBA2Kh9UAdbigf25QiVXYVQ-3ivUWwbyntkNK-pxzY_Q9jP6up_Ed-thuA4w1wF5Z0_3-T_f3neqN8BZbtfyE</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Christou, Evangelos</creator><creator>Mastrogianni, Sotiria</creator><creator>Bourousis, Evangelos</creator><creator>Bachou, Theodora</creator><creator>Tsikrikas, Theodoros</creator><creator>Mouskou, Stella</creator><creator>Voudris, Konstantinos</creator><creator>Delis, Dimitrios</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0001-6575-0134</orcidid></search><sort><creationdate>202202</creationdate><title>Α case of seronegative autoimmune encephalitis associated with human herpesvirus‐7 (HHV‐7)</title><author>Christou, Evangelos ; 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Despite the fact that autoantibodies usually target the neuronal cell surface or synaptic proteins in the central nervous system (CNS), in many cases these remain undetectable, constituting a future diagnostic and therapeutic challenge. Human herpesvirus‐7 (HHV‐7) is proven to be a neurotropic virus, causing various neurological complications mostly in the adult population. We present the case of a 10‐year‐old girl, with confirmed active HHV‐7 infection of the CNS, who developed acute seronegative autoimmune encephalitis. To our best knowledge, there is no literature concerning pediatric cases of autoimmune encephalitis following HHV‐7 infection.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34676889</pmid><doi>10.1002/jmv.27411</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-6575-0134</orcidid></addata></record> |
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| subjects | acute encephalitis Antibodies, Viral - blood Autoantibodies Autoantibodies - cerebrospinal fluid Autoimmune diseases Autoimmune Diseases of the Nervous System - cerebrospinal fluid Brain - pathology Cell surface Central nervous system Child Complications Encephalitis Encephalitis - cerebrospinal fluid Female Herpesvirus 7, Human HHV‐7 infection Humans Infections Magnetic Resonance Imaging Neurological complications Pediatrics Recurrence Roseolovirus Infections - cerebrospinal fluid seronegative autoimmune encephalitis Virology Viruses |
| title | Α case of seronegative autoimmune encephalitis associated with human herpesvirus‐7 (HHV‐7) |
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