Curcumin‐coated gold nanoparticles attenuate doxorubicin‐induced cardiotoxicity via regulating apoptosis in a mouse model

Doxorubicin (DOX) is one of the most widely used chemotherapy agents; however, its nonselective effect causes cardiotoxicity. Curcumin (Cur), a well known dietary polyphenol, could exert a significant cardioprotective effect, but the biological application of this substance is limited by its chemica...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2022-01, Vol.49 (1), p.70-83
Hauptverfasser:	Sharifiaghdam, Zeynab, Dalouchi, Fereshteh, Sharifiaghdam, Maryam, Shaabani, Elnaz, Ramezani, Fatemeh, Nikbakht, Farnaz, Azizi, Yaser
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Bax protein Biological effects Biomarkers Body weight loss Cardiomyocytes Cardiotoxicity Cardiotoxicity - drug therapy Cardiotoxicity - etiology Cardiotoxins - antagonists & inhibitors Cardiotoxins - toxicity Caspase Chemotherapy Curcumin Curcumin - therapeutic use Cytotoxicity Diet Doxorubicin Doxorubicin - antagonists & inhibitors Doxorubicin - toxicity Fourier transforms Gold gold nanoparticles Heart Hemorrhage Infrared spectroscopy Injury prevention Male Metal Nanoparticles Mice Mice, Inbred BALB C Microscopy, Electron, Transmission Nanoparticles Photoelectron Spectroscopy Proteins Spectroscopy Spectroscopy, Fourier Transform Infrared Spectrum analysis Toxicity Transmission electron microscopy Weight loss
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