Opposite effects of cations in enhancing and suppressing nucleation in the pathological crystallization of gout
In this paper, we focused on the influence of common serum cations on monosodium urate monohydrate (MSUM) crystal nucleation determined from cumulative probability distributions (CPDs) of solute crystal nucleation events as a function of time. Surprisingly, with an increase in the concentration of a...
Gespeichert in:
| Veröffentlicht in: | CrystEngComm 2021-12, Vol.23 (47), p.8411-8417 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8417 |
|---|---|
| container_issue | 47 |
| container_start_page | 8411 |
| container_title | CrystEngComm |
| container_volume | 23 |
| creator | Da, Anqi Ren, Aijun Cheng, Rong Zhang, Xingde Pan, Yonglan Ou, Chunyan Fu, Tingming Liu, Yonghai |
| description | In this paper, we focused on the influence of common serum cations on monosodium urate monohydrate (MSUM) crystal nucleation determined from cumulative probability distributions (CPDs) of solute crystal nucleation events as a function of time. Surprisingly, with an increase in the concentration of additive ions, striking "opposite effects" were observed for cations, enhancing nucleation at first followed by suppressing nucleation at physiological pH and ionic strength. This enhancing nucleation phenomenon cannot be explained based on colloidal theories or simple descriptors, such as ion size, but it is consistent with the cationic efficacy for inducing an increase in the proportion of growth units of MSUM.
"Opposite effects" were shown by cations, enhancing nucleation followed by suppressing nucleation at physiological pH and ionic strength. |
| doi_str_mv | 10.1039/d1ce01178b |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_rsc_p</sourceid><recordid>TN_cdi_proquest_journals_2606991438</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2606991438</sourcerecordid><originalsourceid>FETCH-LOGICAL-c281t-d6b0e3de14dfa7a0e9213556ff836d40ea657e5ec761db10dc6161f00fa5e8053</originalsourceid><addsrcrecordid>eNpN0E1Lw0AQBuAgCtbqxbuw4E2IznSTTXrUWj-g0Iuew3Z3tk2Ju3F3c6i_3rQR9TQz8PAOvElyiXCLwKd3GhUBYlGujpIRZkKkJXB-_G8_Tc5C2AJghgijxC3b1oU6EiNjSMXAnGFKxtrZwGrLyG6kVbVdM2k1C13begphf9tONXSAexc3xFoZN65x61rJhim_C1E2Tf01mD527bp4npwY2QS6-Jnj5P1p_jZ7SRfL59fZ_SJVkxJjqsUKiGvCTBtZSKDpBHmeC2NKLnQGJEVeUE6qEKhXCFoJFGgAjMyphJyPk-sht_Xus6MQq63rvO1fVhMBYjrFjJe9uhmU8i4ET6Zqff0h_a5CqPaFVo84mx8Kfejx1YB9UL_ur3D-DYnUdHg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2606991438</pqid></control><display><type>article</type><title>Opposite effects of cations in enhancing and suppressing nucleation in the pathological crystallization of gout</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Da, Anqi ; Ren, Aijun ; Cheng, Rong ; Zhang, Xingde ; Pan, Yonglan ; Ou, Chunyan ; Fu, Tingming ; Liu, Yonghai</creator><creatorcontrib>Da, Anqi ; Ren, Aijun ; Cheng, Rong ; Zhang, Xingde ; Pan, Yonglan ; Ou, Chunyan ; Fu, Tingming ; Liu, Yonghai</creatorcontrib><description>In this paper, we focused on the influence of common serum cations on monosodium urate monohydrate (MSUM) crystal nucleation determined from cumulative probability distributions (CPDs) of solute crystal nucleation events as a function of time. Surprisingly, with an increase in the concentration of additive ions, striking "opposite effects" were observed for cations, enhancing nucleation at first followed by suppressing nucleation at physiological pH and ionic strength. This enhancing nucleation phenomenon cannot be explained based on colloidal theories or simple descriptors, such as ion size, but it is consistent with the cationic efficacy for inducing an increase in the proportion of growth units of MSUM.
"Opposite effects" were shown by cations, enhancing nucleation followed by suppressing nucleation at physiological pH and ionic strength.</description><identifier>ISSN: 1466-8033</identifier><identifier>EISSN: 1466-8033</identifier><identifier>DOI: 10.1039/d1ce01178b</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Cations ; Crystallization ; Crystals ; Nucleation</subject><ispartof>CrystEngComm, 2021-12, Vol.23 (47), p.8411-8417</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c281t-d6b0e3de14dfa7a0e9213556ff836d40ea657e5ec761db10dc6161f00fa5e8053</citedby><cites>FETCH-LOGICAL-c281t-d6b0e3de14dfa7a0e9213556ff836d40ea657e5ec761db10dc6161f00fa5e8053</cites><orcidid>0000-0001-9019-4272</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27913,27914</link.rule.ids></links><search><creatorcontrib>Da, Anqi</creatorcontrib><creatorcontrib>Ren, Aijun</creatorcontrib><creatorcontrib>Cheng, Rong</creatorcontrib><creatorcontrib>Zhang, Xingde</creatorcontrib><creatorcontrib>Pan, Yonglan</creatorcontrib><creatorcontrib>Ou, Chunyan</creatorcontrib><creatorcontrib>Fu, Tingming</creatorcontrib><creatorcontrib>Liu, Yonghai</creatorcontrib><title>Opposite effects of cations in enhancing and suppressing nucleation in the pathological crystallization of gout</title><title>CrystEngComm</title><description>In this paper, we focused on the influence of common serum cations on monosodium urate monohydrate (MSUM) crystal nucleation determined from cumulative probability distributions (CPDs) of solute crystal nucleation events as a function of time. Surprisingly, with an increase in the concentration of additive ions, striking "opposite effects" were observed for cations, enhancing nucleation at first followed by suppressing nucleation at physiological pH and ionic strength. This enhancing nucleation phenomenon cannot be explained based on colloidal theories or simple descriptors, such as ion size, but it is consistent with the cationic efficacy for inducing an increase in the proportion of growth units of MSUM.
"Opposite effects" were shown by cations, enhancing nucleation followed by suppressing nucleation at physiological pH and ionic strength.</description><subject>Cations</subject><subject>Crystallization</subject><subject>Crystals</subject><subject>Nucleation</subject><issn>1466-8033</issn><issn>1466-8033</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpN0E1Lw0AQBuAgCtbqxbuw4E2IznSTTXrUWj-g0Iuew3Z3tk2Ju3F3c6i_3rQR9TQz8PAOvElyiXCLwKd3GhUBYlGujpIRZkKkJXB-_G8_Tc5C2AJghgijxC3b1oU6EiNjSMXAnGFKxtrZwGrLyG6kVbVdM2k1C13begphf9tONXSAexc3xFoZN65x61rJhim_C1E2Tf01mD527bp4npwY2QS6-Jnj5P1p_jZ7SRfL59fZ_SJVkxJjqsUKiGvCTBtZSKDpBHmeC2NKLnQGJEVeUE6qEKhXCFoJFGgAjMyphJyPk-sht_Xus6MQq63rvO1fVhMBYjrFjJe9uhmU8i4ET6Zqff0h_a5CqPaFVo84mx8Kfejx1YB9UL_ur3D-DYnUdHg</recordid><startdate>20211206</startdate><enddate>20211206</enddate><creator>Da, Anqi</creator><creator>Ren, Aijun</creator><creator>Cheng, Rong</creator><creator>Zhang, Xingde</creator><creator>Pan, Yonglan</creator><creator>Ou, Chunyan</creator><creator>Fu, Tingming</creator><creator>Liu, Yonghai</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0001-9019-4272</orcidid></search><sort><creationdate>20211206</creationdate><title>Opposite effects of cations in enhancing and suppressing nucleation in the pathological crystallization of gout</title><author>Da, Anqi ; Ren, Aijun ; Cheng, Rong ; Zhang, Xingde ; Pan, Yonglan ; Ou, Chunyan ; Fu, Tingming ; Liu, Yonghai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-d6b0e3de14dfa7a0e9213556ff836d40ea657e5ec761db10dc6161f00fa5e8053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cations</topic><topic>Crystallization</topic><topic>Crystals</topic><topic>Nucleation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Da, Anqi</creatorcontrib><creatorcontrib>Ren, Aijun</creatorcontrib><creatorcontrib>Cheng, Rong</creatorcontrib><creatorcontrib>Zhang, Xingde</creatorcontrib><creatorcontrib>Pan, Yonglan</creatorcontrib><creatorcontrib>Ou, Chunyan</creatorcontrib><creatorcontrib>Fu, Tingming</creatorcontrib><creatorcontrib>Liu, Yonghai</creatorcontrib><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>CrystEngComm</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Da, Anqi</au><au>Ren, Aijun</au><au>Cheng, Rong</au><au>Zhang, Xingde</au><au>Pan, Yonglan</au><au>Ou, Chunyan</au><au>Fu, Tingming</au><au>Liu, Yonghai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opposite effects of cations in enhancing and suppressing nucleation in the pathological crystallization of gout</atitle><jtitle>CrystEngComm</jtitle><date>2021-12-06</date><risdate>2021</risdate><volume>23</volume><issue>47</issue><spage>8411</spage><epage>8417</epage><pages>8411-8417</pages><issn>1466-8033</issn><eissn>1466-8033</eissn><abstract>In this paper, we focused on the influence of common serum cations on monosodium urate monohydrate (MSUM) crystal nucleation determined from cumulative probability distributions (CPDs) of solute crystal nucleation events as a function of time. Surprisingly, with an increase in the concentration of additive ions, striking "opposite effects" were observed for cations, enhancing nucleation at first followed by suppressing nucleation at physiological pH and ionic strength. This enhancing nucleation phenomenon cannot be explained based on colloidal theories or simple descriptors, such as ion size, but it is consistent with the cationic efficacy for inducing an increase in the proportion of growth units of MSUM.
"Opposite effects" were shown by cations, enhancing nucleation followed by suppressing nucleation at physiological pH and ionic strength.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d1ce01178b</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9019-4272</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1466-8033 |
| ispartof | CrystEngComm, 2021-12, Vol.23 (47), p.8411-8417 |
| issn | 1466-8033 1466-8033 |
| language | eng |
| recordid | cdi_proquest_journals_2606991438 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Cations Crystallization Crystals Nucleation |
| title | Opposite effects of cations in enhancing and suppressing nucleation in the pathological crystallization of gout |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T09%3A20%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_rsc_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Opposite%20effects%20of%20cations%20in%20enhancing%20and%20suppressing%20nucleation%20in%20the%20pathological%20crystallization%20of%20gout&rft.jtitle=CrystEngComm&rft.au=Da,%20Anqi&rft.date=2021-12-06&rft.volume=23&rft.issue=47&rft.spage=8411&rft.epage=8417&rft.pages=8411-8417&rft.issn=1466-8033&rft.eissn=1466-8033&rft_id=info:doi/10.1039/d1ce01178b&rft_dat=%3Cproquest_rsc_p%3E2606991438%3C/proquest_rsc_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2606991438&rft_id=info:pmid/&rfr_iscdi=true |