Effects of Galarmin and Cobra Venom on the Morphofunctional State of the Substantia Nigra in a Rat Model of Parkinson’s Disease
Morphofunctional characteristics of the substantia nigra (SN) were compared in four groups of experimental rats: (i) control (sham-operated), (ii) animals with a rotenone model of Parkinson’s disease, PD (induced by stereotaxic unilateral microinjections of 12 μg into the median forebrain bundle), (...
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| Veröffentlicht in: | Neurophysiology (New York) 2021, Vol.53 (1), p.22-29 |
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| creator | Danielyan, M. H. Кarapetyan, K. V. Nebogova, K. A. Nazaryan, O. H. Khachatryan, V. P. |
| description | Morphofunctional characteristics of the
substantia nigra
(SN) were compared in four groups of experimental rats: (i) control (sham-operated), (ii) animals with a rotenone model of Parkinson’s disease, PD (induced by stereotaxic unilateral microinjections of 12 μg into the median forebrain bundle), (iii) rats with modeled PD treated with i.m. injections of 100 μg/kg galarmin, and (iv) similar rats but treated with i.m. injections of a small dose of cobra venom (
Naja oxiana
venom, 1.0 mg/k, i.e., 5% of LD50). Four weeks after rotenone injection, frontal SN sections of all animals were examined using light microscopy and a technique for detection of Ca
2+
-dependent acid phosphatase. Clear structural disorders in the SN (decreased density of neurons, negative changes in their shape, depigmentation, low activity of acid phosphatase, etc.) were observed in rats of the second group (with the PD model). Such changes were significantly less intense in rats of the third and fourth groups (those also with the PD model, but treated with course introductions of galarmin or small doses of cobra venom); the former agent (galarmin) demonstrated somewhat better neuroprotective effects. |
| doi_str_mv | 10.1007/s11062-021-09909-1 |
| format | Article |
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substantia nigra
(SN) were compared in four groups of experimental rats: (i) control (sham-operated), (ii) animals with a rotenone model of Parkinson’s disease, PD (induced by stereotaxic unilateral microinjections of 12 μg into the median forebrain bundle), (iii) rats with modeled PD treated with i.m. injections of 100 μg/kg galarmin, and (iv) similar rats but treated with i.m. injections of a small dose of cobra venom (
Naja oxiana
venom, 1.0 mg/k, i.e., 5% of LD50). Four weeks after rotenone injection, frontal SN sections of all animals were examined using light microscopy and a technique for detection of Ca
2+
-dependent acid phosphatase. Clear structural disorders in the SN (decreased density of neurons, negative changes in their shape, depigmentation, low activity of acid phosphatase, etc.) were observed in rats of the second group (with the PD model). Such changes were significantly less intense in rats of the third and fourth groups (those also with the PD model, but treated with course introductions of galarmin or small doses of cobra venom); the former agent (galarmin) demonstrated somewhat better neuroprotective effects.</description><identifier>ISSN: 0090-2977</identifier><identifier>EISSN: 1573-9007</identifier><identifier>DOI: 10.1007/s11062-021-09909-1</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acid phosphatase ; Biomedical and Life Sciences ; Biomedicine ; Calcium ; Comparative analysis ; Forebrain ; Functional morphology ; Light microscopy ; Movement disorders ; Naja oxiana ; Neurodegenerative diseases ; Neurons ; Neuroprotection ; Neurosciences ; Parkinson's disease ; Phosphatase ; Phosphatases ; Poisonous snakes ; Rodents ; Rotenone ; Substantia nigra ; Venom</subject><ispartof>Neurophysiology (New York), 2021, Vol.53 (1), p.22-29</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c343t-3398eb4a8848cd4c2a84f7bba7922886db42f1d8defb152ae69292b3e6dec3f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11062-021-09909-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11062-021-09909-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Danielyan, M. H.</creatorcontrib><creatorcontrib>Кarapetyan, K. V.</creatorcontrib><creatorcontrib>Nebogova, K. A.</creatorcontrib><creatorcontrib>Nazaryan, O. H.</creatorcontrib><creatorcontrib>Khachatryan, V. P.</creatorcontrib><title>Effects of Galarmin and Cobra Venom on the Morphofunctional State of the Substantia Nigra in a Rat Model of Parkinson’s Disease</title><title>Neurophysiology (New York)</title><addtitle>Neurophysiology</addtitle><description>Morphofunctional characteristics of the
substantia nigra
(SN) were compared in four groups of experimental rats: (i) control (sham-operated), (ii) animals with a rotenone model of Parkinson’s disease, PD (induced by stereotaxic unilateral microinjections of 12 μg into the median forebrain bundle), (iii) rats with modeled PD treated with i.m. injections of 100 μg/kg galarmin, and (iv) similar rats but treated with i.m. injections of a small dose of cobra venom (
Naja oxiana
venom, 1.0 mg/k, i.e., 5% of LD50). Four weeks after rotenone injection, frontal SN sections of all animals were examined using light microscopy and a technique for detection of Ca
2+
-dependent acid phosphatase. Clear structural disorders in the SN (decreased density of neurons, negative changes in their shape, depigmentation, low activity of acid phosphatase, etc.) were observed in rats of the second group (with the PD model). Such changes were significantly less intense in rats of the third and fourth groups (those also with the PD model, but treated with course introductions of galarmin or small doses of cobra venom); the former agent (galarmin) demonstrated somewhat better neuroprotective effects.</description><subject>Acid phosphatase</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium</subject><subject>Comparative analysis</subject><subject>Forebrain</subject><subject>Functional morphology</subject><subject>Light microscopy</subject><subject>Movement disorders</subject><subject>Naja oxiana</subject><subject>Neurodegenerative diseases</subject><subject>Neurons</subject><subject>Neuroprotection</subject><subject>Neurosciences</subject><subject>Parkinson's disease</subject><subject>Phosphatase</subject><subject>Phosphatases</subject><subject>Poisonous snakes</subject><subject>Rodents</subject><subject>Rotenone</subject><subject>Substantia nigra</subject><subject>Venom</subject><issn>0090-2977</issn><issn>1573-9007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAQxyMEEkvhBThZ4sQhxV9J7GO1lFKpfKgLXK1JMt66ZO3FdiS4wWPwejwJDkFCvSAfRvL8fqMZ_avqKaOnjNLuRWKMtrymnNVUa6prdq_asKYTtS7t-9WGUk1rrrvuYfUopVtKaat0s6l-nFuLQ04kWHIBE8SD8wT8SLahj0A-oQ8HEjzJN0jehHi8CXb2Q3bBw0R2GTIu5tLdzX3K4LMD8tbti7sMIteQizfitGDvIX52PgX_6_vPRF66hJDwcfXAwpTwyd96Un18df5h-7q-endxuT27qgchRa6F0Ap7CUpJNYxy4KCk7foeOs25Uu3YS27ZqEa0PWs4YKu55r3AdsRBWCpOqmfr3GMMX2ZM2dyGOZYzkuEtbVohG90W6nSl9jChcd6GHGEob8SDG4JH68r_WaupbDhnsgjP7wiFyfg172FOyVzuru-yfGWHGFKKaM0xugPEb4ZRs-Ro1hxNydH8ydGwIolVSgX2e4z_9v6P9RsfEaCS</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Danielyan, M. H.</creator><creator>Кarapetyan, K. V.</creator><creator>Nebogova, K. A.</creator><creator>Nazaryan, O. H.</creator><creator>Khachatryan, V. P.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>2021</creationdate><title>Effects of Galarmin and Cobra Venom on the Morphofunctional State of the Substantia Nigra in a Rat Model of Parkinson’s Disease</title><author>Danielyan, M. H. ; Кarapetyan, K. V. ; Nebogova, K. A. ; Nazaryan, O. H. ; Khachatryan, V. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-3398eb4a8848cd4c2a84f7bba7922886db42f1d8defb152ae69292b3e6dec3f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acid phosphatase</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calcium</topic><topic>Comparative analysis</topic><topic>Forebrain</topic><topic>Functional morphology</topic><topic>Light microscopy</topic><topic>Movement disorders</topic><topic>Naja oxiana</topic><topic>Neurodegenerative diseases</topic><topic>Neurons</topic><topic>Neuroprotection</topic><topic>Neurosciences</topic><topic>Parkinson's disease</topic><topic>Phosphatase</topic><topic>Phosphatases</topic><topic>Poisonous snakes</topic><topic>Rodents</topic><topic>Rotenone</topic><topic>Substantia nigra</topic><topic>Venom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Danielyan, M. H.</creatorcontrib><creatorcontrib>Кarapetyan, K. V.</creatorcontrib><creatorcontrib>Nebogova, K. A.</creatorcontrib><creatorcontrib>Nazaryan, O. H.</creatorcontrib><creatorcontrib>Khachatryan, V. P.</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Neurophysiology (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Danielyan, M. H.</au><au>Кarapetyan, K. V.</au><au>Nebogova, K. A.</au><au>Nazaryan, O. H.</au><au>Khachatryan, V. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Galarmin and Cobra Venom on the Morphofunctional State of the Substantia Nigra in a Rat Model of Parkinson’s Disease</atitle><jtitle>Neurophysiology (New York)</jtitle><stitle>Neurophysiology</stitle><date>2021</date><risdate>2021</risdate><volume>53</volume><issue>1</issue><spage>22</spage><epage>29</epage><pages>22-29</pages><issn>0090-2977</issn><eissn>1573-9007</eissn><abstract>Morphofunctional characteristics of the
substantia nigra
(SN) were compared in four groups of experimental rats: (i) control (sham-operated), (ii) animals with a rotenone model of Parkinson’s disease, PD (induced by stereotaxic unilateral microinjections of 12 μg into the median forebrain bundle), (iii) rats with modeled PD treated with i.m. injections of 100 μg/kg galarmin, and (iv) similar rats but treated with i.m. injections of a small dose of cobra venom (
Naja oxiana
venom, 1.0 mg/k, i.e., 5% of LD50). Four weeks after rotenone injection, frontal SN sections of all animals were examined using light microscopy and a technique for detection of Ca
2+
-dependent acid phosphatase. Clear structural disorders in the SN (decreased density of neurons, negative changes in their shape, depigmentation, low activity of acid phosphatase, etc.) were observed in rats of the second group (with the PD model). Such changes were significantly less intense in rats of the third and fourth groups (those also with the PD model, but treated with course introductions of galarmin or small doses of cobra venom); the former agent (galarmin) demonstrated somewhat better neuroprotective effects.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11062-021-09909-1</doi><tpages>8</tpages></addata></record> |
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| subjects | Acid phosphatase Biomedical and Life Sciences Biomedicine Calcium Comparative analysis Forebrain Functional morphology Light microscopy Movement disorders Naja oxiana Neurodegenerative diseases Neurons Neuroprotection Neurosciences Parkinson's disease Phosphatase Phosphatases Poisonous snakes Rodents Rotenone Substantia nigra Venom |
| title | Effects of Galarmin and Cobra Venom on the Morphofunctional State of the Substantia Nigra in a Rat Model of Parkinson’s Disease |
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