The Agonist of Inward Rectifier Potassium Channel (IK1) Attenuates Rat Reperfusion Arrhythmias Linked to CaMKII Signaling

Inward rectifier potassium channels (IK1, Kir) are known to play critical roles in arrhythmogenesis. Thus, how IK1 agonist affects reperfusion arrhythmias needs to be clarified, and its underlying mechanisms should be determined. Reperfusion arrhythmias were modeled by coronary ligation (ischemia, 1...

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Veröffentlicht in:	International Heart Journal 2021/11/29, Vol.62(6), pp.1348-1357
Hauptverfasser:	Liu, Qinghua, Sun, Jiaxing, Zhang, Lijun, Xu, Yanwu, Wu, Bowei, Cao, Jimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Arrhythmia Arrhythmias, Cardiac - drug therapy Benzamides - pharmacology Benzylamines - pharmacology Bridged Bicyclo Compounds, Heterocyclic - pharmacology Ca2+-transporting ATPase Ca2+/calmodulin-dependent protein kinase II Calcium (intracellular) Calcium - metabolism Calcium homeostasis Calcium overload Calcium signalling Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Cardiac arrhythmia Cardiomyocytes Caspase-3 Disease Models, Animal Hypoxia Hypoxia/reoxygenation Ischemia Myocardial Reperfusion Injury - complications Oxidation Oxidative stress Phospholamban Phosphorylation Postconditioning Potassium Potassium channels (inwardly-rectifying) Potassium Channels, Inwardly Rectifying - agonists Preconditioning Protein Kinase Inhibitors - pharmacology Rats Rats, Sprague-Dawley Reactive oxygen species Reperfusion Signal Transduction Sulfonamides - pharmacology Ventricle
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