Population pharmacokinetic simulation of varied Immune Globulin Subcutaneous (Human), 20% solution (Ig20Gly) loading and maintenance dosing regimens in immunoglobulin-naïve patients with primary immunodeficiency diseases

•A PK model simulated Ig20Gly dose regimen scenarios in IG-naïve patients with PID.•Steady-state IgG achieved by around Week 12 for all baseline endogenous IgG levels.•Time to target trough IgG level depended on baseline IgG and Ig20Gly loading scheme.•Simulations indicated that protective IgG level...

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Veröffentlicht in:	International immunopharmacology 2021-11, Vol.100, p.108044, Article 108044
Hauptverfasser:	Li, Zhaoyang, Dumas, Todd, Seth Berry, N., McCoy, Barbara, Yel, Leman
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological Variation, Population Child Child, Preschool Clinical trials Computer Simulation Dosage Drug Administration Schedule Drug therapy Female Globulins Humans Ig20Gly IgG antibody Immune system Immunodeficiency Immunoglobulin G Immunoglobulin G - administration & dosage Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin-naïve Immunoglobulins Immunologic Factors - administration & dosage Immunologic Factors - blood Immunologic Factors - pharmacokinetics Injections, Subcutaneous Maintenance Male Models, Biological Patients Pharmacokinetic modeling Pharmacokinetics Pharmacology Primary immunodeficiencies Primary Immunodeficiency Diseases - drug therapy Primary Immunodeficiency Diseases - immunology Simulation Subcutaneous Therapeutic target Young Adult
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