PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness

The cystine-glutamate antiporter, xCT, supports a glutathione synthesis program enabling cancer cells to cope with metabolically stressful microenvironments. Up-regulated xCT, in combination with glutaminolysis, leads to increased extracellular glutamate, which promotes invasive behavior by activati...

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Veröffentlicht in:	The Journal of cell biology 2021-12, Vol.220 (12), p.1
Hauptverfasser:	Rabas, Nicolas, Palmer, Sarah, Mitchell, Louise, Ismail, Shehab, Gohlke, Andrea, Riley, Joel S, Tait, Stephen W G, Gammage, Payam, Soares, Leandro Lemgruber, Macpherson, Iain R, Norman, Jim C
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cancer Carcinoma Cell Death and Autophagy Cell Line, Tumor Cell Metabolism Cisplatin - pharmacology DNA Packaging - drug effects DNA, Mitochondrial - metabolism Endosomes - drug effects Endosomes - metabolism Extracellular vesicles Extracellular Vesicles - drug effects Extracellular Vesicles - metabolism Extracellular Vesicles - ultrastructure Glutamic acid receptors (metabotropic) Glutathione Humans Invasiveness Mammary gland Microenvironments Mitochondria - drug effects Mitochondria - metabolism Mitochondrial DNA Mitochondrial Proteins - metabolism Neoplasm Invasiveness Protein Kinases - metabolism PTEN-induced putative kinase rab27 GTP-Binding Proteins - metabolism Receptors Receptors, Metabotropic Glutamate - metabolism Tetraspanin 30 - metabolism Toll-Like Receptor 9 - metabolism Toll-like receptors Tumor cells Vesicles
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