Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs

Post-translational modification of proteins by ubiquitin and ubiquitin-like modifiers, such as SUMO, are key events in protein homeostasis or DNA damage response. Smc5/6 is a nuclear multi-subunit complex that participates in the recombinational DNA repair processes and is required in the maintenanc...

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Veröffentlicht in:	Nature communications 2021-12, Vol.12 (1), p.7013-7013, Article 7013
Hauptverfasser:	Varejão, Nathalia, Lascorz, Jara, Codina-Fabra, Joan, Bellí, Gemma, Borràs-Gas, Helena, Torres-Rosell, Jordi, Reverter, David
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/173 631/45/474/2073 631/535/1266 82/83 Basic Helix-Loop-Helix Transcription Factors Biomimetics Cell Cycle Proteins Chromosomes Conjugation Crystal structure Crystallography, X-Ray Damage Deoxyribonucleic acid Discharge DNA DNA Damage DNA repair Domains Homeostasis Humanities and Social Sciences Integrity Interfaces multidisciplinary Multidisciplinary Sciences Post-translation Protein Processing, Post-Translational Proteins Proteostasis Recombinational DNA Repair Repair Repressor Proteins Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Small Ubiquitin-Related Modifier Proteins - chemistry Small Ubiquitin-Related Modifier Proteins - metabolism Substrates Thioesters Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism Ubiquitination Yeasts
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