A Mammalian Target of Rapamycin‐Perilipin 3 (mTORC1‐Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis

Background and Aims NAFLD is the most common hepatic pathology in western countries and no treatment is currently available. NAFLD is characterized by the aberrant hepatocellular accumulation of fatty acids in the form of lipid droplets (LDs). Recently, it was shown that liver LD degradation occurs...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2021-12, Vol.74 (6), p.3441-3459
Hauptverfasser:	Garcia‐Macia, Marina, Santos‐Ledo, Adrián, Leslie, Jack, Paish, Hannah L., Collins, Amy L., Scott, Rebecca S., Watson, Abigail, Burgoyne, Rachel A., White, Steve, French, Jeremy, Hammond, John, Borthwick, Lee A., Mann, Jelena, Bolaños, Juan P., Korolchuk, Viktor I., Oakley, Fiona, Mann, Derek A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Degradation Fatty acids Fatty Liver - metabolism Fibroblasts Hepatocytes Hepatocytes - metabolism Hepatology Humans Liver Male Mechanistic Target of Rapamycin Complex 1 - metabolism Mice Mice, Inbred C57BL Molecular modelling Oleic acid Perilipin-3 - metabolism Phagocytosis Phosphorylation Proteins Rapamycin RNA-mediated interference Signal Transduction TOR protein Toxicity
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