Homeoprotein SIX1 compromises antitumor immunity through TGF-β-mediated regulation of collagens

The tumor microenvironment (TME), including infiltrated immune cells, is known to play an important role in tumor growth; however, the mechanisms underlying tumor immunogenicity have not been fully elucidated. Here, we discovered an unexpected role for the transcription factor SIX1 in regulating the...

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Veröffentlicht in:	Cellular & molecular immunology 2021-12, Vol.18 (12), p.2660-2672
Hauptverfasser:	Liu, Wancheng, Gao, Meiling, Li, Lili, Chen, Yu, Fan, Huimin, Cai, Qiaomei, Shi, Yueyue, Pan, Chaohu, Liu, Junxiao, Cheng, Lucy S., Yang, Heng, Cheng, Genhong
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/327 631/67/580 Antibodies Biomedical and Life Sciences Biomedicine Cancer Cancer immunotherapy Cell activation Cell Line, Tumor Collagen Homeodomain Proteins - metabolism Humans Immunity Immunogenicity Immunology Immunotherapy Infiltration Medical Microbiology Metastases Microbiology Signal Transduction SIX gene family Smad2 protein Transforming Growth Factor beta - metabolism Tumor microenvironment Vaccine
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