Discovery of new indole-based 1,2,4-triazole derivatives as potent tubulin polymerization inhibitors with anticancer activity

Thirty-six novel indole-based 1,2,4-triazole derivatives were designed and synthesized through the molecular hybrid strategy. The bioassay results revealed that 9p displayed excellent antiproliferative efficacies in the nanomolar range against HeLa cells. Importantly, the compound exhibited no obvio...

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Veröffentlicht in:	New journal of chemistry 2021-11, Vol.45 (46), p.21869-2188
Hauptverfasser:	Yang, Fang, Jian, Xie-Er, Chen, Lin, Ma, Yu-Feng, Liu, Yu-Xia, You, Wen-Wei, Zhao, Pei-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Apoptosis Cell cycle Chemical synthesis Colchicine Inhibitors Molecular docking Polymerization Triazoles
Online-Zugang:	Volltext
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