Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice

Aging and aging-related metabolic complications are global problems that seriously threaten public health. Taxifolin (TAX) is a novel health food and has been widely proved to have a variety of biological activities used in food and medicine. However, the delayed effect of TAX on the aging process h...

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Veröffentlicht in:	Food & function 2021-11, Vol.12 (23), p.12142-12158
Hauptverfasser:	Liu, Xing-Long, Zhao, Ying-Chun, Zhu, Hong-Yan, Wu, Ming, Zheng, Yi-Nan, Yang, Min, Cheng, Zhi-Qiang, Ding, Chuan-Bo, Liu, Wen-Cong
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Aging Aging (artificial) Aging (natural) Aging - drug effects AKT protein Animal tissues Animals Antioxidants Apoptosis Brain Brain damage Cholinergics Complications D-Galactose Deceleration Flora Food Galactose Galactose - adverse effects Gastrointestinal Microbiome - drug effects Health risks Heme Heme oxygenase (decyclizing) Injuries Injury analysis Intestinal microflora Intestine Kinases Male Malondialdehyde Maze learning Memory Disorders - chemically induced Memory Disorders - metabolism Metabolic disorders Metabolism Mice Mice, Inbred ICR NADH NADH dehydrogenase Natural & organic foods NF-E2-Related Factor 2 - metabolism Nicotinamide adenine dinucleotide Oxidative stress Oxidative Stress - drug effects Oxygenase Phosphorylation Probiotics Public health Quercetin - analogs & derivatives Quercetin - pharmacology Quinones Reactive oxygen species rRNA 16S Spatial discrimination learning Spatial memory
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