Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein

The autophagic ubiquitin‐like protein LC3 functions through interactions with LC3‐interaction regions (LIRs) of other autophagy proteins, including autophagy receptors, which stands out as a promising protein–protein interaction (PPI) target for the intervention of autophagy. Post‐translational modi...

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Veröffentlicht in:	Angewandte Chemie 2021-12, Vol.133 (50), p.26309-26318
Hauptverfasser:	Fan, Shijie, Yue, Liyan, Wan, Wei, Zhang, Yuanyuan, Zhang, Bidong, Otomo, Chinatsu, Li, Quanfu, Lin, Tingting, Hu, Junchi, Xu, Pan, Zhu, Mingrui, Tao, Hongru, Chen, Zhifeng, Li, Lianchun, Ding, Hong, Yao, Zhiyi, Lu, Junyan, Wen, Yi, Zhang, Naixia, Tan, Minjia, Chen, Kaixian, Xie, Yuli, Otomo, Takanori, Zhou, Bing, Jiang, Hualiang, Dang, Yongjun, Luo, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Autophagy Chemistry Covalence covalent modification HeLa cells LC3 Phagocytosis post-translational modification probes Proteins proteome Selectivity Substrates Therapeutic applications Ubiquitin
Online-Zugang:	Volltext
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