Succinate as a mobilization cue

Succinic acid, being a metabolite of the Krebs cycle and the end product of anaerobic transformations in mitochondria, functions outside mitochondria and cells as a regulatory signal. In the cytosol, micromolar amounts of succinate stabilize the transcriptional hypoxia-inducible factor HIF, which tr...

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Veröffentlicht in:	Cardiometry 2020-11 (17), p.110-120
Hauptverfasser:	Maevsky, Eugene I, Vasilyeva, Anna A, Kozhurin, Mikhail V, Leonard, Paul, Schwarzburd, Polina M, Uchitel, Mikhail I, Zapatrina, Elena A, Maevskaya, Marina E, Bogdanova, Lyudmila A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Dehydrogenases Drug dosages Enzymes Glucose Hypoxia Ischemia Medicine Mitochondria Physiology Transcription factors Tumors
Online-Zugang:	Volltext
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