Recent advances in the direct transformation of propargylic alcohols to allenes
Allenes are the simplest class of cumulenes, possessing unique physical and chemical properties. These structural units are widely used as valuable synthetic intermediates in organic synthesis, as well as the key skeletons of many natural products, biologically active molecules, and pharmaceutical c...
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| Veröffentlicht in: | Organic Chemistry Frontiers 2021-11, Vol.8 (23), p.6760-6782 |
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| creator | Du, Sha Zhou, An-Xi Yang, Ruchun Song, Xian-Rong Xiao, Qiang |
| description | Allenes are the simplest class of cumulenes, possessing unique physical and chemical properties. These structural units are widely used as valuable synthetic intermediates in organic synthesis, as well as the key skeletons of many natural products, biologically active molecules, and pharmaceutical compounds. In recent decades, the development of synthetic methodologies for the synthesis of allenes by direct transformation of propargylic alcohols has attracted considerable attention among organic chemistry researchers. In this review, we focus on recent advances in the direct transformation of propargylic alcohols to allenes. These transformations can be divided into four categories according to their reaction types: (1) reactions with transition metal catalysis; (2) reactions involving carbocation intermediates; (3) reactions that are metal hydride (base)-mediated; and (4) reactions involving oxa-propargylic intermediates. |
| doi_str_mv | 10.1039/D1QO01151K |
| format | Article |
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| ispartof | Organic Chemistry Frontiers, 2021-11, Vol.8 (23), p.6760-6782 |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Alcohol Alcohols Biological activity Catalysis Chemical properties Intermediates Metal hydrides Natural products Organic chemistry Transformations Transition metals |
| title | Recent advances in the direct transformation of propargylic alcohols to allenes |
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