Forced Degradation Studies of Sofosbuvir with a Developed and Validated RP-HPLC Method as per ICH Guidelines

A reverse phase-high-performance liquid chromatography-diode array detector method is developed for the determination of the antiviral drug sofosbuvir in bulk and Sofos ® 400 mg tablet dosage forms. Sofosbuvir is used for the treatment of chronic hepatitis C. The separation is carried out using a gr...

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Veröffentlicht in:	Chromatographia 2021-12, Vol.84 (12), p.1131-1140
Hauptverfasser:	Hamdache, Abderrazaq, Grib, Lamia, Grib, Celia, Adour, Lydia, Zatout, Hakim, Mezrouai, Abderrahmane, Saraoui, Sarah
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Analytical Chemistry Arrays Chemistry Chemistry and Materials Science Chromatography Degradation Flow velocity Hepatitis C High performance liquid chromatography Laboratory Medicine Original Oxidation Pharmacy Photolysis Proteomics
Online-Zugang:	Volltext
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