Therapeutic targeting of the hypoxic tumour microenvironment

Hypoxia is prevalent in human tumours and contributes to microenvironments that shape cancer evolution and adversely affect therapeutic outcomes. Historically, two different tumour microenvironment (TME) research communities have been discernible. One has focused on physicochemical gradients of oxyg...

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Veröffentlicht in:	Nature reviews. Clinical oncology 2021-12, Vol.18 (12), p.751-772
Hauptverfasser:	Singleton, Dean C., Macann, Andrew, Wilson, William R.
Format:	Artikel
Sprache:	eng
Schlagworte:	692/420/755 692/699/67/1059 692/699/67/327 Cancer Cancer cells Care and treatment Cell Hypoxia - drug effects Cell Hypoxia - radiation effects Gene expression Genetic aspects Health aspects Humans Hypoxia Medicine Medicine & Public Health Microenvironments Microvasculature Neoplasms - metabolism Neoplasms - therapy Oncology Oncology, Experimental Oxygen - metabolism Radiation therapy Review Article Signal Transduction - drug effects Solid tumors Therapeutic targets Tumor microenvironment Tumor Microenvironment - drug effects Tumor Microenvironment - radiation effects Tumors
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