miRNA-based biomarkers, therapies, and resistance in Cancer
MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor i...
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| Veröffentlicht in: | International journal of biological sciences 2020-01, Vol.16 (14), p.2628-2647 |
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| container_title | International journal of biological sciences |
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| creator | He, Boxue Zhao, Zhenyu Cai, Qidong Zhang, Yuqian Zhang, Pengfei Shi, Shuai Xie, Hui Peng, Xiong Yin, Wei Tao, Yongguang Wang, Xiang |
| description | MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review. |
| doi_str_mv | 10.7150/ijbs.47203 |
| format | Article |
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A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review.</description><identifier>ISSN: 1449-2288</identifier><identifier>EISSN: 1449-2288</identifier><identifier>DOI: 10.7150/ijbs.47203</identifier><identifier>PMID: 32792861</identifier><language>eng</language><publisher>LAKE HAVEN: Ivyspring Int Publ</publisher><subject>Animals ; Biochemistry & Molecular Biology ; Biology ; Biomarkers ; Biomarkers, Tumor - metabolism ; Biosynthesis ; Cancer ; Cancer screening ; Cognition ; Cytoplasm ; Drug Resistance, Neoplasm ; Enzymes ; Exports ; Gene expression ; Gene regulation ; Genomes ; Humans ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine - Other Topics ; Medical prognosis ; MicroRNAs ; MicroRNAs - biosynthesis ; miRNA ; Molecular Targeted Therapy ; Neoplasms - metabolism ; Neoplasms - therapy ; Nucleotides ; Patients ; Prognosis ; Proteins ; Regulatory mechanisms (biology) ; Review ; RNA polymerase ; Science & Technology ; Transfer RNA ; Tumors</subject><ispartof>International journal of biological sciences, 2020-01, Vol.16 (14), p.2628-2647</ispartof><rights>The author(s).</rights><rights>2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>350</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000555111400011</woscitedreferencesoriginalsourcerecordid><cites>FETCH-LOGICAL-p294t-ad7d3b5b102510f2e3d812c9a16d18653d63b66e350d34b12aa1da7ba44d528e3</cites><orcidid>0000-0002-3211-7153 ; 0000-0003-0311-0697</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415433/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415433/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32792861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Boxue</creatorcontrib><creatorcontrib>Zhao, Zhenyu</creatorcontrib><creatorcontrib>Cai, Qidong</creatorcontrib><creatorcontrib>Zhang, Yuqian</creatorcontrib><creatorcontrib>Zhang, Pengfei</creatorcontrib><creatorcontrib>Shi, Shuai</creatorcontrib><creatorcontrib>Xie, Hui</creatorcontrib><creatorcontrib>Peng, Xiong</creatorcontrib><creatorcontrib>Yin, Wei</creatorcontrib><creatorcontrib>Tao, Yongguang</creatorcontrib><creatorcontrib>Wang, Xiang</creatorcontrib><title>miRNA-based biomarkers, therapies, and resistance in Cancer</title><title>International journal of biological sciences</title><addtitle>INT J BIOL SCI</addtitle><addtitle>Int J Biol Sci</addtitle><description>MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review.</description><subject>Animals</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biosynthesis</subject><subject>Cancer</subject><subject>Cancer screening</subject><subject>Cognition</subject><subject>Cytoplasm</subject><subject>Drug Resistance, Neoplasm</subject><subject>Enzymes</subject><subject>Exports</subject><subject>Gene expression</subject><subject>Gene regulation</subject><subject>Genomes</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Life Sciences & Biomedicine - Other Topics</subject><subject>Medical prognosis</subject><subject>MicroRNAs</subject><subject>MicroRNAs - biosynthesis</subject><subject>miRNA</subject><subject>Molecular Targeted Therapy</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - therapy</subject><subject>Nucleotides</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Regulatory mechanisms (biology)</subject><subject>Review</subject><subject>RNA polymerase</subject><subject>Science & Technology</subject><subject>Transfer RNA</subject><subject>Tumors</subject><issn>1449-2288</issn><issn>1449-2288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkMtKxTAQhoMo3jc-gBTcCFrN5NKmCIIUbyAKouuSNHM0x3OSY9Iqvr31irpyNR_Mx88_Q8gG0L0SJN13Y5P2RMkonyPLIESVM6bU_A9eIispjSnlhVR0kSxxVlZMFbBMDqbu-vIoNzqhzYwLUx0fMKbdrLvHqGcOB9TeZhGTS532LWbOZ_UbxDWyMNKThOufc5Xcnhzf1Gf5xdXpeX10kc9YJbpc29JyIw1QJoGOGHKrgLWVhsKCKiS3BTdFgVxSy4UBpjVYXRothJVMIV8lhx-5s95M0bbou6gnzSy6oe1LE7Rrfm-8u2_uwlNTCpCC8yFg-zMghsceU9dMXWpxMtEeQ58aJrgQJWdVOahbf9Rx6KMfzmuYrJSgDN4DN382-q7y9ddB2PkQntGEUWodDg_71iilUkoAEAPBm63-b9eu050Lvg697_grw8eZDw</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>He, Boxue</creator><creator>Zhao, Zhenyu</creator><creator>Cai, Qidong</creator><creator>Zhang, Yuqian</creator><creator>Zhang, Pengfei</creator><creator>Shi, Shuai</creator><creator>Xie, Hui</creator><creator>Peng, Xiong</creator><creator>Yin, Wei</creator><creator>Tao, Yongguang</creator><creator>Wang, Xiang</creator><general>Ivyspring Int Publ</general><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3211-7153</orcidid><orcidid>https://orcid.org/0000-0003-0311-0697</orcidid></search><sort><creationdate>20200101</creationdate><title>miRNA-based biomarkers, therapies, and resistance in Cancer</title><author>He, Boxue ; 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A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review.</abstract><cop>LAKE HAVEN</cop><pub>Ivyspring Int Publ</pub><pmid>32792861</pmid><doi>10.7150/ijbs.47203</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-3211-7153</orcidid><orcidid>https://orcid.org/0000-0003-0311-0697</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biochemistry & Molecular Biology Biology Biomarkers Biomarkers, Tumor - metabolism Biosynthesis Cancer Cancer screening Cognition Cytoplasm Drug Resistance, Neoplasm Enzymes Exports Gene expression Gene regulation Genomes Humans Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics Medical prognosis MicroRNAs MicroRNAs - biosynthesis miRNA Molecular Targeted Therapy Neoplasms - metabolism Neoplasms - therapy Nucleotides Patients Prognosis Proteins Regulatory mechanisms (biology) Review RNA polymerase Science & Technology Transfer RNA Tumors |
| title | miRNA-based biomarkers, therapies, and resistance in Cancer |
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