Gallium-68 labeled Gd-CdTe quantum dots: a novel nuclear imaging agent for detection of fibrosarcoma tumor
In this study, the influence of incorporation of gadolinium ions in CdTe quantum dots lattice on the biodistribution of [ 68 Ga] Ga@Gd-CdTe QDs nanoparticles was investigated. [ 68 Ga] Ga@Gd-CdTe QDs nanoparticles were prepared using high purity [ 68 Ga] GaCl 3 and thioglycolic acid (TGA) capped Gd-...
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| Veröffentlicht in: | Journal of radioanalytical and nuclear chemistry 2021-12, Vol.330 (3), p.1137-1145 |
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| container_title | Journal of radioanalytical and nuclear chemistry |
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| creator | Gharghani, Shima Fazaeli, Yousef Zare, Hakimeh Feizi, Shahzad Ashtari, Parviz Shahedi, Zahra |
| description | In this study, the influence of incorporation of gadolinium ions in CdTe quantum dots lattice on the biodistribution of [
68
Ga] Ga@Gd-CdTe QDs nanoparticles was investigated. [
68
Ga] Ga@Gd-CdTe QDs nanoparticles were prepared using high purity [
68
Ga] GaCl
3
and thioglycolic acid (TGA) capped Gd-CdTe QDs. TGA capped Gd-CdTe QDs were characterized with high resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), infrared spectroscopy (FTIR), UV–Vis spectroscopy, photoluminescence spectroscopy and vibrating sample magnetometry (VSM). The radiochemical purity and stability of the [
68
Ga] Ga@Gd-CdTe QDs were performed using conventional instant thin layer chromatography. In-vivo biodistribution studies in rats bearing fibrosarcoma tumors were performed by intravenously injection of [
68
Ga] Ga@Gd-CdTe QDs nanocomposite followed by positron emission tomography (PET) imaging. High (8.8%) and rapid (after 24 min) tumor uptake of [
68
Ga] Ga@Gd-CdTe QDs were observed. |
| doi_str_mv | 10.1007/s10967-021-08058-3 |
| format | Article |
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68
Ga] Ga@Gd-CdTe QDs nanoparticles was investigated. [
68
Ga] Ga@Gd-CdTe QDs nanoparticles were prepared using high purity [
68
Ga] GaCl
3
and thioglycolic acid (TGA) capped Gd-CdTe QDs. TGA capped Gd-CdTe QDs were characterized with high resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), infrared spectroscopy (FTIR), UV–Vis spectroscopy, photoluminescence spectroscopy and vibrating sample magnetometry (VSM). The radiochemical purity and stability of the [
68
Ga] Ga@Gd-CdTe QDs were performed using conventional instant thin layer chromatography. In-vivo biodistribution studies in rats bearing fibrosarcoma tumors were performed by intravenously injection of [
68
Ga] Ga@Gd-CdTe QDs nanocomposite followed by positron emission tomography (PET) imaging. High (8.8%) and rapid (after 24 min) tumor uptake of [
68
Ga] Ga@Gd-CdTe QDs were observed.</description><identifier>ISSN: 0236-5731</identifier><identifier>EISSN: 1588-2780</identifier><identifier>DOI: 10.1007/s10967-021-08058-3</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biodistribution ; Cadmium tellurides ; Chemistry ; Chemistry and Materials Science ; Chromatography ; Diagnostic Radiology ; Diffraction ; Fibrosarcoma ; Gadolinium ; Gallium chloride ; Gallium isotopes ; Hadrons ; Heavy Ions ; High resolution electron microscopy ; Infrared spectroscopy ; Inorganic Chemistry ; Magnetic measurement ; Nanocomposites ; Nanoparticles ; Nuclear Chemistry ; Nuclear Physics ; Photoluminescence ; Photovoltaic cells ; Physical Chemistry ; Positron emission ; Purity ; Quantum dots ; Radiochemistry ; Spectrum analysis ; Thin layer chromatography ; Tomography ; Tumors ; X-ray spectroscopy ; X-rays</subject><ispartof>Journal of radioanalytical and nuclear chemistry, 2021-12, Vol.330 (3), p.1137-1145</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Akadémiai Kiadó, Budapest, Hungary 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-9a0f5c4f407456d4ee8a2e4e63ce333dfa5a6b05a10cfee93811508c96214db63</citedby><cites>FETCH-LOGICAL-c386t-9a0f5c4f407456d4ee8a2e4e63ce333dfa5a6b05a10cfee93811508c96214db63</cites><orcidid>0000-0002-3952-2987</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10967-021-08058-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10967-021-08058-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Gharghani, Shima</creatorcontrib><creatorcontrib>Fazaeli, Yousef</creatorcontrib><creatorcontrib>Zare, Hakimeh</creatorcontrib><creatorcontrib>Feizi, Shahzad</creatorcontrib><creatorcontrib>Ashtari, Parviz</creatorcontrib><creatorcontrib>Shahedi, Zahra</creatorcontrib><title>Gallium-68 labeled Gd-CdTe quantum dots: a novel nuclear imaging agent for detection of fibrosarcoma tumor</title><title>Journal of radioanalytical and nuclear chemistry</title><addtitle>J Radioanal Nucl Chem</addtitle><description>In this study, the influence of incorporation of gadolinium ions in CdTe quantum dots lattice on the biodistribution of [
68
Ga] Ga@Gd-CdTe QDs nanoparticles was investigated. [
68
Ga] Ga@Gd-CdTe QDs nanoparticles were prepared using high purity [
68
Ga] GaCl
3
and thioglycolic acid (TGA) capped Gd-CdTe QDs. TGA capped Gd-CdTe QDs were characterized with high resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), infrared spectroscopy (FTIR), UV–Vis spectroscopy, photoluminescence spectroscopy and vibrating sample magnetometry (VSM). The radiochemical purity and stability of the [
68
Ga] Ga@Gd-CdTe QDs were performed using conventional instant thin layer chromatography. In-vivo biodistribution studies in rats bearing fibrosarcoma tumors were performed by intravenously injection of [
68
Ga] Ga@Gd-CdTe QDs nanocomposite followed by positron emission tomography (PET) imaging. High (8.8%) and rapid (after 24 min) tumor uptake of [
68
Ga] Ga@Gd-CdTe QDs were observed.</description><subject>Biodistribution</subject><subject>Cadmium tellurides</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography</subject><subject>Diagnostic Radiology</subject><subject>Diffraction</subject><subject>Fibrosarcoma</subject><subject>Gadolinium</subject><subject>Gallium chloride</subject><subject>Gallium isotopes</subject><subject>Hadrons</subject><subject>Heavy Ions</subject><subject>High resolution electron microscopy</subject><subject>Infrared spectroscopy</subject><subject>Inorganic Chemistry</subject><subject>Magnetic measurement</subject><subject>Nanocomposites</subject><subject>Nanoparticles</subject><subject>Nuclear Chemistry</subject><subject>Nuclear Physics</subject><subject>Photoluminescence</subject><subject>Photovoltaic cells</subject><subject>Physical Chemistry</subject><subject>Positron emission</subject><subject>Purity</subject><subject>Quantum dots</subject><subject>Radiochemistry</subject><subject>Spectrum analysis</subject><subject>Thin layer chromatography</subject><subject>Tomography</subject><subject>Tumors</subject><subject>X-ray spectroscopy</subject><subject>X-rays</subject><issn>0236-5731</issn><issn>1588-2780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU9rHSEUxSW0kNe0X6ArIWvT6zg6Tnbh0b4WAtkka_HpdfAxo4nOFPrta_sKoVCKiwtyfuf-OYR85HDDAYZPlcOoBgYdZ6BBaiYuyI5LrVk3aHhDdtAJxeQg-CV5V-sJAEatxY6cDnae47YwpelsjzijpwfP9v4R6ctm07ot1Oe13lJLU_6OM02bm9EWGhc7xTRRO2FaaciFelzRrTEnmgMN8VhytcXlxdLmkst78jbYueKHP_WKPH35_Lj_yu4fDt_2d_fMCa1WNloI0vWhh6GXyveI2nbYoxIOhRA-WGnVEaTl4ALiKDTnErQbVcd7f1TiilyffZ9LftmwruaUt5JaS9PJcZAwSNW_qiY7o4kp5LVYt8TqzJ3Sneyb7dhUN_9QtedxiS4nDLH9_wV0Z8C17WvBYJ5Lu1T5YTiYX1GZc1SmRWV-R2VEg8QZqk2cJiyvE_-H-gnl-JUl</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Gharghani, Shima</creator><creator>Fazaeli, Yousef</creator><creator>Zare, Hakimeh</creator><creator>Feizi, Shahzad</creator><creator>Ashtari, Parviz</creator><creator>Shahedi, Zahra</creator><general>Springer International Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-3952-2987</orcidid></search><sort><creationdate>20211201</creationdate><title>Gallium-68 labeled Gd-CdTe quantum dots: a novel nuclear imaging agent for detection of fibrosarcoma tumor</title><author>Gharghani, Shima ; Fazaeli, Yousef ; Zare, Hakimeh ; Feizi, Shahzad ; Ashtari, Parviz ; Shahedi, Zahra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-9a0f5c4f407456d4ee8a2e4e63ce333dfa5a6b05a10cfee93811508c96214db63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biodistribution</topic><topic>Cadmium tellurides</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chromatography</topic><topic>Diagnostic Radiology</topic><topic>Diffraction</topic><topic>Fibrosarcoma</topic><topic>Gadolinium</topic><topic>Gallium chloride</topic><topic>Gallium isotopes</topic><topic>Hadrons</topic><topic>Heavy Ions</topic><topic>High resolution electron microscopy</topic><topic>Infrared spectroscopy</topic><topic>Inorganic Chemistry</topic><topic>Magnetic measurement</topic><topic>Nanocomposites</topic><topic>Nanoparticles</topic><topic>Nuclear Chemistry</topic><topic>Nuclear Physics</topic><topic>Photoluminescence</topic><topic>Photovoltaic cells</topic><topic>Physical Chemistry</topic><topic>Positron emission</topic><topic>Purity</topic><topic>Quantum dots</topic><topic>Radiochemistry</topic><topic>Spectrum analysis</topic><topic>Thin layer chromatography</topic><topic>Tomography</topic><topic>Tumors</topic><topic>X-ray spectroscopy</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gharghani, Shima</creatorcontrib><creatorcontrib>Fazaeli, Yousef</creatorcontrib><creatorcontrib>Zare, Hakimeh</creatorcontrib><creatorcontrib>Feizi, Shahzad</creatorcontrib><creatorcontrib>Ashtari, Parviz</creatorcontrib><creatorcontrib>Shahedi, Zahra</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gharghani, Shima</au><au>Fazaeli, Yousef</au><au>Zare, Hakimeh</au><au>Feizi, Shahzad</au><au>Ashtari, Parviz</au><au>Shahedi, Zahra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gallium-68 labeled Gd-CdTe quantum dots: a novel nuclear imaging agent for detection of fibrosarcoma tumor</atitle><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle><stitle>J Radioanal Nucl Chem</stitle><date>2021-12-01</date><risdate>2021</risdate><volume>330</volume><issue>3</issue><spage>1137</spage><epage>1145</epage><pages>1137-1145</pages><issn>0236-5731</issn><eissn>1588-2780</eissn><abstract>In this study, the influence of incorporation of gadolinium ions in CdTe quantum dots lattice on the biodistribution of [
68
Ga] Ga@Gd-CdTe QDs nanoparticles was investigated. [
68
Ga] Ga@Gd-CdTe QDs nanoparticles were prepared using high purity [
68
Ga] GaCl
3
and thioglycolic acid (TGA) capped Gd-CdTe QDs. TGA capped Gd-CdTe QDs were characterized with high resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), infrared spectroscopy (FTIR), UV–Vis spectroscopy, photoluminescence spectroscopy and vibrating sample magnetometry (VSM). The radiochemical purity and stability of the [
68
Ga] Ga@Gd-CdTe QDs were performed using conventional instant thin layer chromatography. In-vivo biodistribution studies in rats bearing fibrosarcoma tumors were performed by intravenously injection of [
68
Ga] Ga@Gd-CdTe QDs nanocomposite followed by positron emission tomography (PET) imaging. High (8.8%) and rapid (after 24 min) tumor uptake of [
68
Ga] Ga@Gd-CdTe QDs were observed.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s10967-021-08058-3</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3952-2987</orcidid></addata></record> |
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| source | SpringerNature Journals |
| subjects | Biodistribution Cadmium tellurides Chemistry Chemistry and Materials Science Chromatography Diagnostic Radiology Diffraction Fibrosarcoma Gadolinium Gallium chloride Gallium isotopes Hadrons Heavy Ions High resolution electron microscopy Infrared spectroscopy Inorganic Chemistry Magnetic measurement Nanocomposites Nanoparticles Nuclear Chemistry Nuclear Physics Photoluminescence Photovoltaic cells Physical Chemistry Positron emission Purity Quantum dots Radiochemistry Spectrum analysis Thin layer chromatography Tomography Tumors X-ray spectroscopy X-rays |
| title | Gallium-68 labeled Gd-CdTe quantum dots: a novel nuclear imaging agent for detection of fibrosarcoma tumor |
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