Supramolecular Self‐Assembled DNA Nanosystem for Synergistic Chemical and Gene Regulations on Cancer Cells

Incorporating multiple molecular interactions within a system to realize the metabolic reprogramming of cancer cells is prospected to be of great potential in cancer therapy. Herein, we report a supramolecular self‐assembled DNA nanosystem, which reprogrammed the cellular antioxidant system via syne...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-11, Vol.60 (48), p.25557-25566
Hauptverfasser:	Li, Feng, Lv, Zhaoyue, Zhang, Xue, Dong, Yuhang, Ding, Xiaohui, Li, Zhemian, Li, Shuai, Yao, Chi, Yang, Dayong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antioxidants Antioxidants - chemistry Antioxidants - metabolism Cancer Cell Proliferation - drug effects Cytoplasm Deoxyribonucleic acid Detoxification DNA DNA - chemistry DNA - metabolism DNA nanostructure DNA nanotechnology Drug Screening Assays, Antitumor Gene Expression Regulation - drug effects gene therapy Humans Macromolecular Substances - chemistry Macromolecular Substances - metabolism Macromolecular Substances - pharmacology Manganese - chemistry Manganese - metabolism MCF-7 Cells Micelles Molecular interactions nanomedicine Nanoparticles - chemistry Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - genetics Oxidative stress Particle Size Regulations supramolecular self-assembly Surface Properties
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