Carbol fuchsin stain enhances detection of poly‐(d, l‐lactide‐co‐glycolide) microspheres in exenatide extended‐release cutaneous injection‐site foreign body reaction

Injection of high‐viscosity fluids into subcutaneous tissues may lead to a granulomatous reaction called sclerosing lipogranuloma (SL). Poly‐(d,l‐lactide‐co‐glycolide) (PLG or PLGA) microspheres are used as vehicles for extended‐release drugs. Here we describe the histopathologic features of a case...

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Veröffentlicht in:Journal of cutaneous pathology 2021-12, Vol.48 (12), p.1520-1522
Hauptverfasser: Flugrad, Rebecca, Hoerres, Derek, Googe, Paul B
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Sprache:eng
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Zusammenfassung:Injection of high‐viscosity fluids into subcutaneous tissues may lead to a granulomatous reaction called sclerosing lipogranuloma (SL). Poly‐(d,l‐lactide‐co‐glycolide) (PLG or PLGA) microspheres are used as vehicles for extended‐release drugs. Here we describe the histopathologic features of a case of SL induced by exenatide extended‐release injections, and the staining pattern of PLG microspheres and microsphere remnants with carbol fuchsin.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.14110