Resistance to veterinary antimicrobials of Staphylococcus aureus from mastitic milk
Background Use of antimicrobials in veterinary medicine for prophylactic and therapeutic purposes is one of the main culprits for the selection of antimicrobial resistant bugs that currently threaten human and animal health. Therefore, surveillance on antimicrobial resistance (AMR) selection trends...
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| Veröffentlicht in: | European journal of public health 2021-10, Vol.31 (Supplement_3) |
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| creator | Rossi, F Marino, L Pomilio, F Centorotola, G Cornacchia, A Perilli, M Scattolini, S Telera, GC Del Matto, I |
| description | Background
Use of antimicrobials in veterinary medicine for prophylactic and therapeutic purposes is one of the main culprits for the selection of antimicrobial resistant bugs that currently threaten human and animal health. Therefore, surveillance on antimicrobial resistance (AMR) selection trends in animal husbandry is of utmost importance to prevent the spread of resistant bugs to humans. The species Staphylococcus aureus (Sa), that is of particular concern for the spread of methicillin-resistant (MRSA) strains, often causes mastitis in milk producing animals, thus requiring antibiotic treatment that can impact on the AMR status of this pathogen. With the aim of elucidating the current evolution of AMR in Sa involved in mastitis and the threats posed by the consumption of raw milk or inadequately pasteurized dairy products, data from antimicrobial susceptibility testing carried out on Sa strains from mastitis in years 2013 - 2019 in Molise region, Italy, were analyzed.
Methods
Sa isolates were tested by disk diffusion and inhibition halo sizes were converted in Minimum inhibitory concentrations (MIC) according to the EUCAST standards for the antibiotics there included. One isolate per AMR profile per farm was considered to define the percentage of the antibiotic resistant on the total number of isolates per year.
Results
The number of diagnosed Sa infections per year ranged between seven and nineteen, with a total of 78 isolates from 70 farms. The percentages of those resistant to aminoglycosides kanamycin, neomycin and paromomycin, to the macrolide tylosin and the multi drug resistant (MDR) isolates increased since 2015. The latter ranged between 26.3 and 85.7%.
Conclusions
AMR and MDR Sa in milk producing animals pose a serious risk to public health and needs stricter surveillance.
Key messages
Limiting use of antibiotics is needed to revert the trend.
AMR Sa strains in dairy products, need to be kept under control for the strict connection with human health. |
| doi_str_mv | 10.1093/eurpub/ckab165.289 |
| format | Article |
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Use of antimicrobials in veterinary medicine for prophylactic and therapeutic purposes is one of the main culprits for the selection of antimicrobial resistant bugs that currently threaten human and animal health. Therefore, surveillance on antimicrobial resistance (AMR) selection trends in animal husbandry is of utmost importance to prevent the spread of resistant bugs to humans. The species Staphylococcus aureus (Sa), that is of particular concern for the spread of methicillin-resistant (MRSA) strains, often causes mastitis in milk producing animals, thus requiring antibiotic treatment that can impact on the AMR status of this pathogen. With the aim of elucidating the current evolution of AMR in Sa involved in mastitis and the threats posed by the consumption of raw milk or inadequately pasteurized dairy products, data from antimicrobial susceptibility testing carried out on Sa strains from mastitis in years 2013 - 2019 in Molise region, Italy, were analyzed.
Methods
Sa isolates were tested by disk diffusion and inhibition halo sizes were converted in Minimum inhibitory concentrations (MIC) according to the EUCAST standards for the antibiotics there included. One isolate per AMR profile per farm was considered to define the percentage of the antibiotic resistant on the total number of isolates per year.
Results
The number of diagnosed Sa infections per year ranged between seven and nineteen, with a total of 78 isolates from 70 farms. The percentages of those resistant to aminoglycosides kanamycin, neomycin and paromomycin, to the macrolide tylosin and the multi drug resistant (MDR) isolates increased since 2015. The latter ranged between 26.3 and 85.7%.
Conclusions
AMR and MDR Sa in milk producing animals pose a serious risk to public health and needs stricter surveillance.
Key messages
Limiting use of antibiotics is needed to revert the trend.
AMR Sa strains in dairy products, need to be kept under control for the strict connection with human health.</description><identifier>ISSN: 1101-1262</identifier><identifier>EISSN: 1464-360X</identifier><identifier>DOI: 10.1093/eurpub/ckab165.289</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aminoglycosides ; Animal health ; Animal husbandry ; Animals ; Antibiotic resistance ; Antibiotics ; Antimicrobial agents ; Antimicrobial resistance ; Dairy products ; Drug resistance ; Farms ; Kanamycin ; Livestock industry ; Mastitis ; Methicillin ; Milk ; Minimum inhibitory concentration ; Neomycin ; Paromomycin ; Pasteurization ; Pathogens ; Public health ; Resistance ; Staphylococcus aureus ; Surveillance ; Therapeutic applications ; Tylosin ; Veterinary medicine</subject><ispartof>European journal of public health, 2021-10, Vol.31 (Supplement_3)</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1604,27866,27924,27925</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/eurpub/ckab165.289$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc></links><search><creatorcontrib>Rossi, F</creatorcontrib><creatorcontrib>Marino, L</creatorcontrib><creatorcontrib>Pomilio, F</creatorcontrib><creatorcontrib>Centorotola, G</creatorcontrib><creatorcontrib>Cornacchia, A</creatorcontrib><creatorcontrib>Perilli, M</creatorcontrib><creatorcontrib>Scattolini, S</creatorcontrib><creatorcontrib>Telera, GC</creatorcontrib><creatorcontrib>Del Matto, I</creatorcontrib><title>Resistance to veterinary antimicrobials of Staphylococcus aureus from mastitic milk</title><title>European journal of public health</title><description>Background
Use of antimicrobials in veterinary medicine for prophylactic and therapeutic purposes is one of the main culprits for the selection of antimicrobial resistant bugs that currently threaten human and animal health. Therefore, surveillance on antimicrobial resistance (AMR) selection trends in animal husbandry is of utmost importance to prevent the spread of resistant bugs to humans. The species Staphylococcus aureus (Sa), that is of particular concern for the spread of methicillin-resistant (MRSA) strains, often causes mastitis in milk producing animals, thus requiring antibiotic treatment that can impact on the AMR status of this pathogen. With the aim of elucidating the current evolution of AMR in Sa involved in mastitis and the threats posed by the consumption of raw milk or inadequately pasteurized dairy products, data from antimicrobial susceptibility testing carried out on Sa strains from mastitis in years 2013 - 2019 in Molise region, Italy, were analyzed.
Methods
Sa isolates were tested by disk diffusion and inhibition halo sizes were converted in Minimum inhibitory concentrations (MIC) according to the EUCAST standards for the antibiotics there included. One isolate per AMR profile per farm was considered to define the percentage of the antibiotic resistant on the total number of isolates per year.
Results
The number of diagnosed Sa infections per year ranged between seven and nineteen, with a total of 78 isolates from 70 farms. The percentages of those resistant to aminoglycosides kanamycin, neomycin and paromomycin, to the macrolide tylosin and the multi drug resistant (MDR) isolates increased since 2015. The latter ranged between 26.3 and 85.7%.
Conclusions
AMR and MDR Sa in milk producing animals pose a serious risk to public health and needs stricter surveillance.
Key messages
Limiting use of antibiotics is needed to revert the trend.
AMR Sa strains in dairy products, need to be kept under control for the strict connection with human health.</description><subject>Aminoglycosides</subject><subject>Animal health</subject><subject>Animal husbandry</subject><subject>Animals</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial resistance</subject><subject>Dairy products</subject><subject>Drug resistance</subject><subject>Farms</subject><subject>Kanamycin</subject><subject>Livestock industry</subject><subject>Mastitis</subject><subject>Methicillin</subject><subject>Milk</subject><subject>Minimum inhibitory concentration</subject><subject>Neomycin</subject><subject>Paromomycin</subject><subject>Pasteurization</subject><subject>Pathogens</subject><subject>Public health</subject><subject>Resistance</subject><subject>Staphylococcus aureus</subject><subject>Surveillance</subject><subject>Therapeutic applications</subject><subject>Tylosin</subject><subject>Veterinary medicine</subject><issn>1101-1262</issn><issn>1464-360X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>7TQ</sourceid><recordid>eNqNkMFKAzEQhoMoWKsv4Cngedsku9nNHqWoFQqCVfAWkjjBtN3NmmSFvr2R7QN4-ufw_TPMh9AtJQtK2nIJYxhGvTR7pWnNF0y0Z2hGq7oqypp8nOeZElpQVrNLdBXjjhDCG8FmaPsK0cWkegM4efwDCYLrVThi1SfXORO8duoQsbd4m9TwdTx4440ZI1ZjgBw2-A53KiaXnMGdO-yv0YXNFbg55Ry9Pz68rdbF5uXpeXW_KQzlZVs0pBHaatUA-WyACUqBMg2KaCGqStgSlKjLljW8VrYmVdUqm0HbKi2YBVbO0d20dwj-e4SY5M6Poc8nJeNtwzjlgmSKTVR-JcYAVg7BdflDSYn8kycnefIkT2Z5uVRMJT8O_-F_AcKWdm0</recordid><startdate>20211020</startdate><enddate>20211020</enddate><creator>Rossi, F</creator><creator>Marino, L</creator><creator>Pomilio, F</creator><creator>Centorotola, G</creator><creator>Cornacchia, A</creator><creator>Perilli, M</creator><creator>Scattolini, S</creator><creator>Telera, GC</creator><creator>Del Matto, I</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TQ</scope><scope>C1K</scope><scope>DHY</scope><scope>DON</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20211020</creationdate><title>Resistance to veterinary antimicrobials of Staphylococcus aureus from mastitic milk</title><author>Rossi, F ; Marino, L ; Pomilio, F ; Centorotola, G ; Cornacchia, A ; Perilli, M ; Scattolini, S ; Telera, GC ; Del Matto, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1539-7078bfba7e0d7e2811e12bea0b88448f3ea86392756af60449afd7ef9ab82fe23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aminoglycosides</topic><topic>Animal health</topic><topic>Animal husbandry</topic><topic>Animals</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Antimicrobial resistance</topic><topic>Dairy products</topic><topic>Drug resistance</topic><topic>Farms</topic><topic>Kanamycin</topic><topic>Livestock industry</topic><topic>Mastitis</topic><topic>Methicillin</topic><topic>Milk</topic><topic>Minimum inhibitory concentration</topic><topic>Neomycin</topic><topic>Paromomycin</topic><topic>Pasteurization</topic><topic>Pathogens</topic><topic>Public health</topic><topic>Resistance</topic><topic>Staphylococcus aureus</topic><topic>Surveillance</topic><topic>Therapeutic applications</topic><topic>Tylosin</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rossi, F</creatorcontrib><creatorcontrib>Marino, L</creatorcontrib><creatorcontrib>Pomilio, F</creatorcontrib><creatorcontrib>Centorotola, G</creatorcontrib><creatorcontrib>Cornacchia, A</creatorcontrib><creatorcontrib>Perilli, M</creatorcontrib><creatorcontrib>Scattolini, S</creatorcontrib><creatorcontrib>Telera, GC</creatorcontrib><creatorcontrib>Del Matto, I</creatorcontrib><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>PAIS Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PAIS International</collection><collection>PAIS International (Ovid)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>European journal of public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Rossi, F</au><au>Marino, L</au><au>Pomilio, F</au><au>Centorotola, G</au><au>Cornacchia, A</au><au>Perilli, M</au><au>Scattolini, S</au><au>Telera, GC</au><au>Del Matto, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistance to veterinary antimicrobials of Staphylococcus aureus from mastitic milk</atitle><jtitle>European journal of public health</jtitle><date>2021-10-20</date><risdate>2021</risdate><volume>31</volume><issue>Supplement_3</issue><issn>1101-1262</issn><eissn>1464-360X</eissn><abstract>Background
Use of antimicrobials in veterinary medicine for prophylactic and therapeutic purposes is one of the main culprits for the selection of antimicrobial resistant bugs that currently threaten human and animal health. Therefore, surveillance on antimicrobial resistance (AMR) selection trends in animal husbandry is of utmost importance to prevent the spread of resistant bugs to humans. The species Staphylococcus aureus (Sa), that is of particular concern for the spread of methicillin-resistant (MRSA) strains, often causes mastitis in milk producing animals, thus requiring antibiotic treatment that can impact on the AMR status of this pathogen. With the aim of elucidating the current evolution of AMR in Sa involved in mastitis and the threats posed by the consumption of raw milk or inadequately pasteurized dairy products, data from antimicrobial susceptibility testing carried out on Sa strains from mastitis in years 2013 - 2019 in Molise region, Italy, were analyzed.
Methods
Sa isolates were tested by disk diffusion and inhibition halo sizes were converted in Minimum inhibitory concentrations (MIC) according to the EUCAST standards for the antibiotics there included. One isolate per AMR profile per farm was considered to define the percentage of the antibiotic resistant on the total number of isolates per year.
Results
The number of diagnosed Sa infections per year ranged between seven and nineteen, with a total of 78 isolates from 70 farms. The percentages of those resistant to aminoglycosides kanamycin, neomycin and paromomycin, to the macrolide tylosin and the multi drug resistant (MDR) isolates increased since 2015. The latter ranged between 26.3 and 85.7%.
Conclusions
AMR and MDR Sa in milk producing animals pose a serious risk to public health and needs stricter surveillance.
Key messages
Limiting use of antibiotics is needed to revert the trend.
AMR Sa strains in dairy products, need to be kept under control for the strict connection with human health.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1093/eurpub/ckab165.289</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aminoglycosides Animal health Animal husbandry Animals Antibiotic resistance Antibiotics Antimicrobial agents Antimicrobial resistance Dairy products Drug resistance Farms Kanamycin Livestock industry Mastitis Methicillin Milk Minimum inhibitory concentration Neomycin Paromomycin Pasteurization Pathogens Public health Resistance Staphylococcus aureus Surveillance Therapeutic applications Tylosin Veterinary medicine |
| title | Resistance to veterinary antimicrobials of Staphylococcus aureus from mastitic milk |
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