Electrically controlled transdermal ibuprofen delivery consisting of pectin-bacterial cellulose/polypyrrole hydrogel composites
Pectin/bacteria cellulose (BC) hydrogel composites with various BC contents have been fabricated for the purpose of electrically controlled transdermal drug delivery. A conductive polymer, polypyrrole, was successfully incorporated into the pectin/BC hydrogel composite as a host of drug encapsulatio...
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| Veröffentlicht in: | Cellulose (London) 2021-12, Vol.28 (18), p.11451-11463 |
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| creator | Krathumkhet, Nattinee Imae, Toyoko Paradee, Nophawan |
| description | Pectin/bacteria cellulose (BC) hydrogel composites with various BC contents have been fabricated for the purpose of electrically controlled transdermal drug delivery. A conductive polymer, polypyrrole, was successfully incorporated into the pectin/BC hydrogel composite as a host of drug encapsulation for controlled release under applied electric field. Ibuprofen as a model drug was studied for its release behavior based on the effects of matrix composition, pH stimulation, matrix mesh size, and applied electrical potential by using a modified Franz diffusion cell. The drug release was optimized at 30 wt% BC and increased with applying electrical potential. The highest amount of drug release was 78% which was obtained on a drug-loaded polypyrrole-incorporated composite under applied electrical potential at 7 V. The hydrogel composites also presented the remarkable benefit of antibacterial activity for gram-positive bacteria. Thus, the hydrogel composites are valuable alternative materials for transdermal drug delivery.
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| doi_str_mv | 10.1007/s10570-021-04259-x |
| format | Article |
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Graphic abstract</description><subject>Bacteria</subject><subject>Bioorganic Chemistry</subject><subject>Cellulose</subject><subject>Ceramics</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Composite materials</subject><subject>Composites</subject><subject>Composition effects</subject><subject>Conducting polymers</subject><subject>Controlled release</subject><subject>Diffusion cells</subject><subject>Electric fields</subject><subject>Electric potential</subject><subject>Finite element method</subject><subject>Glass</subject><subject>Gram-positive bacteria</subject><subject>Hydrogels</subject><subject>Ibuprofen</subject><subject>Natural Materials</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Organic Chemistry</subject><subject>Original Research</subject><subject>Pectin</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Polypyrroles</subject><subject>Sustainable Development</subject><subject>Transdermal medication</subject><issn>0969-0239</issn><issn>1572-882X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kEtLAzEUhYMoWKt_wNWA69gk88hkKaU-oOBGwV3IZG5qSjoZk6l0Vv51Y0dw5-bexT3nXM6H0DUlt5QQvoiUlJxgwigmBSsFPpygGS05w3XN3k7RjIhKpHMuztFFjFtCiOCMztDXyoEegtXKuTHTvhuCdw7abAiqiy2EnXKZbfZ98Aa6rAVnPyEcldHGwXabzJusTxm2w43SAwSbHBqc2zsfYdF7N_ZjSKmQvY9t8BtIZ7_rfbQDxEt0ZpSLcPW75-j1fvWyfMTr54en5d0a65yKAbeGtwoaYirFOORFKlundqIWbW7aNEVDOVEaKgK1aUxVNELlAIVuDBfM5HN0M-WmIh97iIPc-n3o0kuZcFU1ZUVZJhWbVDr4GAMY2Qe7U2GUlMgf0HICLRNoeQQtD8mUT6aYxN0Gwl_0P65vMHaHGg</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Krathumkhet, Nattinee</creator><creator>Imae, Toyoko</creator><creator>Paradee, Nophawan</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20211201</creationdate><title>Electrically controlled transdermal ibuprofen delivery consisting of pectin-bacterial cellulose/polypyrrole hydrogel composites</title><author>Krathumkhet, Nattinee ; Imae, Toyoko ; Paradee, Nophawan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-df7daeb0f6a27e345708572989d3fd89d9b170ace60e8fbf64b9a3ee4cbf792f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bacteria</topic><topic>Bioorganic Chemistry</topic><topic>Cellulose</topic><topic>Ceramics</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Composite materials</topic><topic>Composites</topic><topic>Composition effects</topic><topic>Conducting polymers</topic><topic>Controlled release</topic><topic>Diffusion cells</topic><topic>Electric fields</topic><topic>Electric potential</topic><topic>Finite element method</topic><topic>Glass</topic><topic>Gram-positive bacteria</topic><topic>Hydrogels</topic><topic>Ibuprofen</topic><topic>Natural Materials</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Organic Chemistry</topic><topic>Original Research</topic><topic>Pectin</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Polypyrroles</topic><topic>Sustainable Development</topic><topic>Transdermal medication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krathumkhet, Nattinee</creatorcontrib><creatorcontrib>Imae, Toyoko</creatorcontrib><creatorcontrib>Paradee, Nophawan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Cellulose (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krathumkhet, Nattinee</au><au>Imae, Toyoko</au><au>Paradee, Nophawan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrically controlled transdermal ibuprofen delivery consisting of pectin-bacterial cellulose/polypyrrole hydrogel composites</atitle><jtitle>Cellulose (London)</jtitle><stitle>Cellulose</stitle><date>2021-12-01</date><risdate>2021</risdate><volume>28</volume><issue>18</issue><spage>11451</spage><epage>11463</epage><pages>11451-11463</pages><issn>0969-0239</issn><eissn>1572-882X</eissn><abstract>Pectin/bacteria cellulose (BC) hydrogel composites with various BC contents have been fabricated for the purpose of electrically controlled transdermal drug delivery. A conductive polymer, polypyrrole, was successfully incorporated into the pectin/BC hydrogel composite as a host of drug encapsulation for controlled release under applied electric field. Ibuprofen as a model drug was studied for its release behavior based on the effects of matrix composition, pH stimulation, matrix mesh size, and applied electrical potential by using a modified Franz diffusion cell. The drug release was optimized at 30 wt% BC and increased with applying electrical potential. The highest amount of drug release was 78% which was obtained on a drug-loaded polypyrrole-incorporated composite under applied electrical potential at 7 V. The hydrogel composites also presented the remarkable benefit of antibacterial activity for gram-positive bacteria. Thus, the hydrogel composites are valuable alternative materials for transdermal drug delivery.
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| subjects | Bacteria Bioorganic Chemistry Cellulose Ceramics Chemistry Chemistry and Materials Science Composite materials Composites Composition effects Conducting polymers Controlled release Diffusion cells Electric fields Electric potential Finite element method Glass Gram-positive bacteria Hydrogels Ibuprofen Natural Materials Nonsteroidal anti-inflammatory drugs Organic Chemistry Original Research Pectin Physical Chemistry Polymer Sciences Polypyrroles Sustainable Development Transdermal medication |
| title | Electrically controlled transdermal ibuprofen delivery consisting of pectin-bacterial cellulose/polypyrrole hydrogel composites |
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