Acute and subacute toxicity evaluation of Houttuynia cordata ethanol extract and plasma metabolic profiling analysis in both male and female rats

Houttuynia cordata has been used as a traditional medicine for more than 1500 years. It has aroused wide public concern about its safety in the past few years, for it contains various aristolactams. However, the safety of H. cordata extract remains unclear. In the present study, single dose (2000 mg...

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Veröffentlicht in:	Journal of applied toxicology 2021-12, Vol.41 (12), p.2068-2082
Hauptverfasser:	Chen, Hongjiang, Sha, Xiuxiu, Luo, Yiyuan, Chen, Jianwei, Li, Xiang, Wang, Juan, Cao, Gang, Peng, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Energy metabolism Ethanol Female hematology Hepatotoxicity histopathology Houttuynia - chemistry Houttuynia cordata Kidneys Lipid metabolism Lipids Male Males Metabolism Metabolome - drug effects metabolomics Oral administration oral toxicity Plant Extracts - chemistry Plant Extracts - toxicity Public concern Rats Rats, Sprague-Dawley Rodents Safety serum biochemistry analysis Side effects Subacute toxicity Toxicity Toxicity Tests, Acute Toxicity Tests, Subacute Traditional medicine
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