A new antidiabetic foot bacteria formula from marine chitosan nanosilver-metal complex
In more than two-thirds of the diabetic foot ulcer (DFUs) cases, lower limb amputation of foot ulceration is caused by the infection. The role of transition a metal complex as a therapeutic compound is becoming increasingly important. In vitro, four groups of antibiotics and one sulfa drug were test...
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| Veröffentlicht in: | Environmental science and pollution research international 2021-11, Vol.28 (43), p.60833-60841 |
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| creator | Ghonam, Hasnaa E-B. Abu Yousef, Morsy A. Gohar, Yousry M. Almeer, Rafa Barakat, Khouloud M. |
| description | In more than two-thirds of the diabetic foot ulcer (DFUs) cases, lower limb amputation of foot ulceration is caused by the infection. The role of transition a metal complex as a therapeutic compound is becoming increasingly important. In vitro, four groups of antibiotics and one sulfa drug were tested against diabetic foot resistant bacteria. Using three concentrations of two different prepared metal complexes: copper (Cu) and silver (Ag) — isoniazid (Iso) and nicotinamide (Nicot) were tested against diabetic foot isolates. Results revealed that β-lactam drugs (cephradine and piperacillin) showed the minimum averages of MIC 265 μg/ml against Gram-positive and Gram-negative isolates. Silver isoniazid (Iso-Ag-1) metal complex was selected depending on the maximum averages of MIC against both types of clinical isolates. The combination between β-lactams and Iso-Ag-1 showed maximum FICI averages of 0.24 for Gram-positive and 0.28 for Gram-negative. In addition, a combination between Iso-Ag-1 with squilla chitosan nanoparticles (CSSq-nAg) showed averages of synergistic index by 0.23 against
Staphylococcus aureus
and 0.13, 0.30, and 0.27 against
E. coli
,
K. pneumoniae
, and
Ps. aeruginosa
, respectively. Final formula of Iso-Ag-1+CSSq-nAg + β-lactams (cephradine and piperacillin) showed a synergistic effect at FICI = 0.044 and 0.047, against G+ve and –ve, respectively. These two combinations showed a slight toxicity against the water flea
Daphnia magna
by 3.49 and 3.6 ppm, respectively. Results suggest the use of Iso-Ag-1-CSSq-nAg as enhancing agent in combination with β-lactams as a blind therapy in pharmaceutical preparations. |
| doi_str_mv | 10.1007/s11356-021-14958-4 |
| format | Article |
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Staphylococcus aureus
and 0.13, 0.30, and 0.27 against
E. coli
,
K. pneumoniae
, and
Ps. aeruginosa
, respectively. Final formula of Iso-Ag-1+CSSq-nAg + β-lactams (cephradine and piperacillin) showed a synergistic effect at FICI = 0.044 and 0.047, against G+ve and –ve, respectively. These two combinations showed a slight toxicity against the water flea
Daphnia magna
by 3.49 and 3.6 ppm, respectively. Results suggest the use of Iso-Ag-1-CSSq-nAg as enhancing agent in combination with β-lactams as a blind therapy in pharmaceutical preparations.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-021-14958-4</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amides ; Amputation ; Antibiotics ; Antidiabetics ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Bacteria ; Cephradine ; Chemical compounds ; Chitosan ; Clinical isolates ; Coordination compounds ; Copper ; Diabetes ; Diabetes mellitus ; E coli ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Feet ; Foot diseases ; Isoniazid ; Metal complexes ; Metal concentrations ; Minimum inhibitory concentration ; Nanoparticles ; Nicotinamide ; Pharmacology ; Piperacillin ; Research Article ; Silver ; Synergistic effect ; Toxicity ; Waste Water Technology ; Water Management ; Water pollution ; Water Pollution Control ; β-Lactam antibiotics</subject><ispartof>Environmental science and pollution research international, 2021-11, Vol.28 (43), p.60833-60841</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-2a0309c18c7e08921094051874aaf8334630969f893b772aa1166f652b5352833</citedby><cites>FETCH-LOGICAL-c352t-2a0309c18c7e08921094051874aaf8334630969f893b772aa1166f652b5352833</cites><orcidid>0000-0002-4133-2058</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-021-14958-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-021-14958-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Ghonam, Hasnaa E-B.</creatorcontrib><creatorcontrib>Abu Yousef, Morsy A.</creatorcontrib><creatorcontrib>Gohar, Yousry M.</creatorcontrib><creatorcontrib>Almeer, Rafa</creatorcontrib><creatorcontrib>Barakat, Khouloud M.</creatorcontrib><title>A new antidiabetic foot bacteria formula from marine chitosan nanosilver-metal complex</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><description>In more than two-thirds of the diabetic foot ulcer (DFUs) cases, lower limb amputation of foot ulceration is caused by the infection. The role of transition a metal complex as a therapeutic compound is becoming increasingly important. In vitro, four groups of antibiotics and one sulfa drug were tested against diabetic foot resistant bacteria. Using three concentrations of two different prepared metal complexes: copper (Cu) and silver (Ag) — isoniazid (Iso) and nicotinamide (Nicot) were tested against diabetic foot isolates. Results revealed that β-lactam drugs (cephradine and piperacillin) showed the minimum averages of MIC 265 μg/ml against Gram-positive and Gram-negative isolates. Silver isoniazid (Iso-Ag-1) metal complex was selected depending on the maximum averages of MIC against both types of clinical isolates. The combination between β-lactams and Iso-Ag-1 showed maximum FICI averages of 0.24 for Gram-positive and 0.28 for Gram-negative. In addition, a combination between Iso-Ag-1 with squilla chitosan nanoparticles (CSSq-nAg) showed averages of synergistic index by 0.23 against
Staphylococcus aureus
and 0.13, 0.30, and 0.27 against
E. coli
,
K. pneumoniae
, and
Ps. aeruginosa
, respectively. Final formula of Iso-Ag-1+CSSq-nAg + β-lactams (cephradine and piperacillin) showed a synergistic effect at FICI = 0.044 and 0.047, against G+ve and –ve, respectively. These two combinations showed a slight toxicity against the water flea
Daphnia magna
by 3.49 and 3.6 ppm, respectively. Results suggest the use of Iso-Ag-1-CSSq-nAg as enhancing agent in combination with β-lactams as a blind therapy in pharmaceutical preparations.</description><subject>Amides</subject><subject>Amputation</subject><subject>Antibiotics</subject><subject>Antidiabetics</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bacteria</subject><subject>Cephradine</subject><subject>Chemical compounds</subject><subject>Chitosan</subject><subject>Clinical isolates</subject><subject>Coordination compounds</subject><subject>Copper</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>E coli</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Feet</subject><subject>Foot diseases</subject><subject>Isoniazid</subject><subject>Metal complexes</subject><subject>Metal concentrations</subject><subject>Minimum inhibitory concentration</subject><subject>Nanoparticles</subject><subject>Nicotinamide</subject><subject>Pharmacology</subject><subject>Piperacillin</subject><subject>Research Article</subject><subject>Silver</subject><subject>Synergistic effect</subject><subject>Toxicity</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water pollution</subject><subject>Water Pollution Control</subject><subject>β-Lactam 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new antidiabetic foot bacteria formula from marine chitosan nanosilver-metal complex</title><author>Ghonam, Hasnaa E-B. ; Abu Yousef, Morsy A. ; Gohar, Yousry M. ; Almeer, Rafa ; Barakat, Khouloud M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-2a0309c18c7e08921094051874aaf8334630969f893b772aa1166f652b5352833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amides</topic><topic>Amputation</topic><topic>Antibiotics</topic><topic>Antidiabetics</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Bacteria</topic><topic>Cephradine</topic><topic>Chemical compounds</topic><topic>Chitosan</topic><topic>Clinical isolates</topic><topic>Coordination compounds</topic><topic>Copper</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>E coli</topic><topic>Earth and Environmental 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Res</stitle><date>2021-11-01</date><risdate>2021</risdate><volume>28</volume><issue>43</issue><spage>60833</spage><epage>60841</epage><pages>60833-60841</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>In more than two-thirds of the diabetic foot ulcer (DFUs) cases, lower limb amputation of foot ulceration is caused by the infection. The role of transition a metal complex as a therapeutic compound is becoming increasingly important. In vitro, four groups of antibiotics and one sulfa drug were tested against diabetic foot resistant bacteria. Using three concentrations of two different prepared metal complexes: copper (Cu) and silver (Ag) — isoniazid (Iso) and nicotinamide (Nicot) were tested against diabetic foot isolates. Results revealed that β-lactam drugs (cephradine and piperacillin) showed the minimum averages of MIC 265 μg/ml against Gram-positive and Gram-negative isolates. Silver isoniazid (Iso-Ag-1) metal complex was selected depending on the maximum averages of MIC against both types of clinical isolates. The combination between β-lactams and Iso-Ag-1 showed maximum FICI averages of 0.24 for Gram-positive and 0.28 for Gram-negative. In addition, a combination between Iso-Ag-1 with squilla chitosan nanoparticles (CSSq-nAg) showed averages of synergistic index by 0.23 against
Staphylococcus aureus
and 0.13, 0.30, and 0.27 against
E. coli
,
K. pneumoniae
, and
Ps. aeruginosa
, respectively. Final formula of Iso-Ag-1+CSSq-nAg + β-lactams (cephradine and piperacillin) showed a synergistic effect at FICI = 0.044 and 0.047, against G+ve and –ve, respectively. These two combinations showed a slight toxicity against the water flea
Daphnia magna
by 3.49 and 3.6 ppm, respectively. Results suggest the use of Iso-Ag-1-CSSq-nAg as enhancing agent in combination with β-lactams as a blind therapy in pharmaceutical preparations.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s11356-021-14958-4</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4133-2058</orcidid></addata></record> |
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| ispartof | Environmental science and pollution research international, 2021-11, Vol.28 (43), p.60833-60841 |
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| language | eng |
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| subjects | Amides Amputation Antibiotics Antidiabetics Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bacteria Cephradine Chemical compounds Chitosan Clinical isolates Coordination compounds Copper Diabetes Diabetes mellitus E coli Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Feet Foot diseases Isoniazid Metal complexes Metal concentrations Minimum inhibitory concentration Nanoparticles Nicotinamide Pharmacology Piperacillin Research Article Silver Synergistic effect Toxicity Waste Water Technology Water Management Water pollution Water Pollution Control β-Lactam antibiotics |
| title | A new antidiabetic foot bacteria formula from marine chitosan nanosilver-metal complex |
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