HSP70 promotes tumor progression by stabilizing Skp2 expression in gastric cancer cells

Gastric cancer (GC) has one of the highest tumor incidences worldwide. Heat shock protein 70 (HSP70) is highly expressed and plays a critical role in the occurrence, progression, metastasis, poor prognosis, and drug resistance of GC. However, the underlying mechanisms of HSP70 are not clear. To expl...

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Veröffentlicht in:	Molecular carcinogenesis 2021-12, Vol.60 (12), p.826-839
Hauptverfasser:	Lei, Ziying, Xia, Xiaohong, He, Qiaoling, Luo, Jiali, Xiong, Yan, Wang, Jin, Tang, Hongsheng, Guan, Tianpei, Tian, Yun, Xu, Songhui, Cui, Shuzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell cycle Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cholecystokinin Disease Progression Drug resistance Female Gastric cancer Gene Expression Regulation, Neoplastic - drug effects Genomes Heat shock proteins HSP70 HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Humans Immunofluorescence Immunohistochemistry Kinases Localization Male Metastases Oxaliplatin - pharmacology Prognosis Protein expression Protein Stability Proteins Purine Nucleosides - pharmacology S phase S-Phase Kinase-Associated Proteins - chemistry S-Phase Kinase-Associated Proteins - metabolism Skp2 Stomach Neoplasms - metabolism thermochemotherapy tumor progression Tumors Up-Regulation - drug effects
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