Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

The emergence of mutant K13-mediated artemisinin (ART) resistance in malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, propeller genotyping confirms the emergence of the R561H mutation in Rwanda and highlights the continuing dominance of wild-type K13 elsew...

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Veröffentlicht in:	eLife 2021-07, Vol.10
Hauptverfasser:	Stokes, Barbara H, Dhingra, Satish K, Rubiano, Kelly, Mok, Sachel, Straimer, Judith, Gnädig, Nina F, Deni, Ioanna, Schindler, Kyra A, Bath, Jade R, Ward, Kurt E, Striepen, Josefine, Yeo, Tomas, Ross, Leila S, Legrand, Eric, Ariey, Frédéric, Cunningham, Clark H, Souleymane, Issa M, Gansané, Adama, Nzoumbou-Boko, Romaric, Ndayikunda, Claudette, Kabanywanyi, Abdunoor M, Uwimana, Aline, Smith, Samuel J, Kolley, Olimatou, Ndounga, Mathieu, Warsame, Marian, Leang, Rithea, Nosten, François, Anderson, Timothy Jc, Rosenthal, Philip J, Ménard, Didier, Fidock, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa Antimalarials - pharmacology Artemisinin artemisinin resistance Artemisinins - pharmacology Asia Autosomal dominant inheritance Cambodia CRISPR/Cas9 Drug Resistance - drug effects Drug Resistance - genetics drug-resistance efficacy Epidemiology and Global Health Ferredoxin fitness Folkhälsovetenskap, global hälsa och socialmedicin Gene mutations Genetic aspects Genome editing Genotype & phenotype Genotyping Human health and pathology Humans Infectious diseases Life Sciences Life Sciences & Biomedicine - Other Topics Malaria Malaria, Falciparum - epidemiology Malaria, Falciparum - parasitology Microbiology and Infectious Disease Microbiology and Parasitology Molecular Epidemiology Mutation Parasite resistance Parasites Parasitology pfcrt pfmdr1 Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Protozoan Proteins - genetics Public Health, Global Health and Social Medicine Reproductive fitness return ring-stage survival Severe acute respiratory syndrome coronavirus 2 spread Strains (organisms)
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