HMO-4 Immunogenicity to second anti-TNF therapy (IMSAT): implications for sequencing of biologic therapy

IntroductionAnti-TNF treatment failure in patients with IBD is common. International guidelines recommend switching out of class when anti-TNF drug levels are therapeutic and within class with an immunomodulator when anti-TNF drug levels are suboptimal and associated with antibody development.We sou...

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Veröffentlicht in:	Gut 2021-11, Vol.70 (Suppl 4), p.A31-A32
Hauptverfasser:	Chanchlani, Neil, Lin, Simeng, Thomas, Amanda, Hamilton, Ben, Nice, Rachel, Chee, Desmond, Kennedy, Nick, Goodhand, James, Ahmad, Tariq
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Crohn's disease Enzyme-linked immunosorbent assay GLP-1 receptor agonists Immunogenicity Immunomodulation Infliximab Monoclonal antibodies Patients Pharmacodynamics Posters – highly commended Therapeutic drug monitoring Tumor necrosis factor-α
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