A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children
There is emerging evidence demonstrating an association between maternal polycystic ovary syndrome (PCOS) and autism spectrum disorder (ASD) in children, however, the cumulative effect of maternal PCOS on the development of ASD or other neuropsychiatry disorders (NPD) in children and separately for...
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| Veröffentlicht in: | Translational psychiatry 2021-11, Vol.11 (1), p.569-569, Article 569 |
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| creator | Dubey, Pallavi Thakur, Bhaskar Rodriguez, Sheryl Cox, Jessika Sanchez, Sheralyn Fonseca, Anacani Reddy, Sireesha Clegg, Deborah Dwivedi, Alok Kumar |
| description | There is emerging evidence demonstrating an association between maternal polycystic ovary syndrome (PCOS) and autism spectrum disorder (ASD) in children, however, the cumulative effect of maternal PCOS on the development of ASD or other neuropsychiatry disorders (NPD) in children and separately for males and females has not been examined. We sought to systematically evaluate the influence of maternal PCOS on a wide range of NPD including ASD, attention deficit hyperactivity disorder (ADHD), chronic tic disorder (CDT), other behavior disorders, anxiety, depression, bipolar disorder, schizophrenia in children as well as in women of reproductive age only. We queried electronic databases including PubMed, EMBASE, and Google Scholar, until March 2021. We used DerSimonian and Laird (D-L) random effects method to compute pooled effect size in terms of odds ratio (OR). Nineteen studies (1667851 mothers, 2260622 children) were included in this study. Mothers with PCOS had an increased odds of children diagnosed with ASD (OR = 1.40,
p
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| doi_str_mv | 10.1038/s41398-021-01699-8 |
| format | Article |
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p
< 0.001), ADHD (OR = 1.42,
p
< 0.001), CTD (OR = 1.44,
p
= 0.001), anxiety (OR = 1.33,
p
< 0.001), as well as other behavioral symptoms (OR = 1.45,
p
< 0.001) in the adjusted analysis. The association between maternal PCOS and ASD (OR: 1.43 vs. 1.66), ADHD (OR: 1.39 vs. 1.54), and CTD (OR: 1.42 vs. 1.51) was found to be significantly consistent between males and females, respectively. Our data do not suggest increased fetal testosterone exposure is associated with increased autistic traits in children. However, PCOS was significantly associated with increased odds of a wide range of NPD in women themselves. Maternal PCOS is a risk factor for various NPD with a similar extent in their children regardless of their underlying comorbidities. Managing PCOS is essential for women’s health as well as for their children’s health. More research is needed to determine the mechanisms and links between maternal PCOS and NPD in children.</description><identifier>ISSN: 2158-3188</identifier><identifier>EISSN: 2158-3188</identifier><identifier>DOI: 10.1038/s41398-021-01699-8</identifier><identifier>PMID: 34750348</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53/2423 ; 692/699/476/1373 ; 706/648 ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Attention deficit hyperactivity disorder ; Autism ; Autism Spectrum Disorder - epidemiology ; Behavioral Sciences ; Biological Psychology ; Child ; Female ; Humans ; Life Sciences & Biomedicine ; Male ; Medicine ; Medicine & Public Health ; Meta-analysis ; Mothers ; Neurosciences ; Ovaries ; Pharmacotherapy ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - epidemiology ; Psychiatry ; Science & Technology ; Systematic Review ; Tic Disorders</subject><ispartof>Translational psychiatry, 2021-11, Vol.11 (1), p.569-569, Article 569</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>13</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000715809100004</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c540t-4635db0a6cda898549aed94ad53ed06a4c218a5791e64cd40c5b3162802d93713</citedby><cites>FETCH-LOGICAL-c540t-4635db0a6cda898549aed94ad53ed06a4c218a5791e64cd40c5b3162802d93713</cites><orcidid>0000-0001-6869-8968 ; 0000-0003-4574-1761</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575994/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575994/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2116,27931,27932,39264,39265,41127,42196,51583,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34750348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dubey, Pallavi</creatorcontrib><creatorcontrib>Thakur, Bhaskar</creatorcontrib><creatorcontrib>Rodriguez, Sheryl</creatorcontrib><creatorcontrib>Cox, Jessika</creatorcontrib><creatorcontrib>Sanchez, Sheralyn</creatorcontrib><creatorcontrib>Fonseca, Anacani</creatorcontrib><creatorcontrib>Reddy, Sireesha</creatorcontrib><creatorcontrib>Clegg, Deborah</creatorcontrib><creatorcontrib>Dwivedi, Alok Kumar</creatorcontrib><title>A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children</title><title>Translational psychiatry</title><addtitle>Transl Psychiatry</addtitle><addtitle>TRANSL PSYCHIAT</addtitle><addtitle>Transl Psychiatry</addtitle><description>There is emerging evidence demonstrating an association between maternal polycystic ovary syndrome (PCOS) and autism spectrum disorder (ASD) in children, however, the cumulative effect of maternal PCOS on the development of ASD or other neuropsychiatry disorders (NPD) in children and separately for males and females has not been examined. We sought to systematically evaluate the influence of maternal PCOS on a wide range of NPD including ASD, attention deficit hyperactivity disorder (ADHD), chronic tic disorder (CDT), other behavior disorders, anxiety, depression, bipolar disorder, schizophrenia in children as well as in women of reproductive age only. We queried electronic databases including PubMed, EMBASE, and Google Scholar, until March 2021. We used DerSimonian and Laird (D-L) random effects method to compute pooled effect size in terms of odds ratio (OR). Nineteen studies (1667851 mothers, 2260622 children) were included in this study. Mothers with PCOS had an increased odds of children diagnosed with ASD (OR = 1.40,
p
< 0.001), ADHD (OR = 1.42,
p
< 0.001), CTD (OR = 1.44,
p
= 0.001), anxiety (OR = 1.33,
p
< 0.001), as well as other behavioral symptoms (OR = 1.45,
p
< 0.001) in the adjusted analysis. The association between maternal PCOS and ASD (OR: 1.43 vs. 1.66), ADHD (OR: 1.39 vs. 1.54), and CTD (OR: 1.42 vs. 1.51) was found to be significantly consistent between males and females, respectively. Our data do not suggest increased fetal testosterone exposure is associated with increased autistic traits in children. However, PCOS was significantly associated with increased odds of a wide range of NPD in women themselves. Maternal PCOS is a risk factor for various NPD with a similar extent in their children regardless of their underlying comorbidities. Managing PCOS is essential for women’s health as well as for their children’s health. More research is needed to determine the mechanisms and links between maternal PCOS and NPD in children.</description><subject>692/53/2423</subject><subject>692/699/476/1373</subject><subject>706/648</subject><subject>Attention Deficit Disorder with Hyperactivity - epidemiology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Autism</subject><subject>Autism Spectrum Disorder - epidemiology</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Mothers</subject><subject>Neurosciences</subject><subject>Ovaries</subject><subject>Pharmacotherapy</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - complications</subject><subject>Polycystic Ovary Syndrome - 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Social Sciences Citation Index – 2021</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Translational psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dubey, Pallavi</au><au>Thakur, Bhaskar</au><au>Rodriguez, Sheryl</au><au>Cox, Jessika</au><au>Sanchez, Sheralyn</au><au>Fonseca, Anacani</au><au>Reddy, Sireesha</au><au>Clegg, Deborah</au><au>Dwivedi, Alok Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children</atitle><jtitle>Translational psychiatry</jtitle><stitle>Transl Psychiatry</stitle><stitle>TRANSL PSYCHIAT</stitle><addtitle>Transl Psychiatry</addtitle><date>2021-11-08</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>569</spage><epage>569</epage><pages>569-569</pages><artnum>569</artnum><issn>2158-3188</issn><eissn>2158-3188</eissn><abstract>There is emerging evidence demonstrating an association between maternal polycystic ovary syndrome (PCOS) and autism spectrum disorder (ASD) in children, however, the cumulative effect of maternal PCOS on the development of ASD or other neuropsychiatry disorders (NPD) in children and separately for males and females has not been examined. We sought to systematically evaluate the influence of maternal PCOS on a wide range of NPD including ASD, attention deficit hyperactivity disorder (ADHD), chronic tic disorder (CDT), other behavior disorders, anxiety, depression, bipolar disorder, schizophrenia in children as well as in women of reproductive age only. We queried electronic databases including PubMed, EMBASE, and Google Scholar, until March 2021. We used DerSimonian and Laird (D-L) random effects method to compute pooled effect size in terms of odds ratio (OR). Nineteen studies (1667851 mothers, 2260622 children) were included in this study. Mothers with PCOS had an increased odds of children diagnosed with ASD (OR = 1.40,
p
< 0.001), ADHD (OR = 1.42,
p
< 0.001), CTD (OR = 1.44,
p
= 0.001), anxiety (OR = 1.33,
p
< 0.001), as well as other behavioral symptoms (OR = 1.45,
p
< 0.001) in the adjusted analysis. The association between maternal PCOS and ASD (OR: 1.43 vs. 1.66), ADHD (OR: 1.39 vs. 1.54), and CTD (OR: 1.42 vs. 1.51) was found to be significantly consistent between males and females, respectively. Our data do not suggest increased fetal testosterone exposure is associated with increased autistic traits in children. However, PCOS was significantly associated with increased odds of a wide range of NPD in women themselves. Maternal PCOS is a risk factor for various NPD with a similar extent in their children regardless of their underlying comorbidities. Managing PCOS is essential for women’s health as well as for their children’s health. More research is needed to determine the mechanisms and links between maternal PCOS and NPD in children.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34750348</pmid><doi>10.1038/s41398-021-01699-8</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6869-8968</orcidid><orcidid>https://orcid.org/0000-0003-4574-1761</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/53/2423 692/699/476/1373 706/648 Attention Deficit Disorder with Hyperactivity - epidemiology Attention deficit hyperactivity disorder Autism Autism Spectrum Disorder - epidemiology Behavioral Sciences Biological Psychology Child Female Humans Life Sciences & Biomedicine Male Medicine Medicine & Public Health Meta-analysis Mothers Neurosciences Ovaries Pharmacotherapy Polycystic ovary syndrome Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - epidemiology Psychiatry Science & Technology Systematic Review Tic Disorders |
| title | A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children |
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