Malignant phyllodes tumour of the breast mimicking endometriosis
A 63-year-old woman presented with a clinically malignant mass. Core biopsy showed features resembling endometriosis. The glands were GATA3 and oestrogen receptor positive consistent with mammary origin and had no myoepithelial layer. The excision also showed a fibroepithelial component with stromal...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2021-11, Vol.479 (5), p.1051-1053 |
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| container_title | Virchows Archiv : an international journal of pathology |
| container_volume | 479 |
| creator | Lee, Andrew H. S. Zanetto, Ulises Awasthi, Rachna Hwang, Mei-Ju Nasir, Nur Diyana Md Ng, Cedric Chuan Young Teh, Bin Tean Tan, Puay Hoon |
| description | A 63-year-old woman presented with a clinically malignant mass. Core biopsy showed features resembling endometriosis. The glands were GATA3 and oestrogen receptor positive consistent with mammary origin and had no myoepithelial layer. The excision also showed a fibroepithelial component with stromal overgrowth, frequent mitoses and invasive margin consistent with a malignant phyllodes tumour. KMT2D and SETD2 mutations were present in both the conventional phyllodes tumour and endometriosis-like areas and are also described in endometriosis raising interesting questions about these lesions. This unusual pattern is a potential diagnostic pitfall, so it is helpful to be aware of it. |
| doi_str_mv | 10.1007/s00428-021-03086-6 |
| format | Article |
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KMT2D and SETD2 mutations were present in both the conventional phyllodes tumour and endometriosis-like areas and are also described in endometriosis raising interesting questions about these lesions. This unusual pattern is a potential diagnostic pitfall, so it is helpful to be aware of it.</description><subject>Biopsy</subject><subject>Breast</subject><subject>Breast cancer</subject><subject>Brief Report</subject><subject>Endometriosis</subject><subject>GATA-3 protein</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mimicry</subject><subject>Mitosis</subject><subject>Mutation</subject><subject>Pathology</subject><subject>Tumors</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAyxQJNaG8SO2swNVvKQiFrC3nMRJU_IotrPo32NIgR2rWcy5d0YHoXMCVwRAXnsAThUGSjAwUAKLAzQnnFFMGchDNIeMp1gwImfoxPsNRFIRcYxmjElFJSdzdPNs2qbuTR-S7XrXtkNpfRLGbhhdMlRJWNskd9b4kHRN1xTvTV8nti-HzgbXDL7xp-ioMq23Z_u5QK_3d2_LR7x6eXha3q5wwTgNOJe0KIUxlGUpAQUZWFbSkudGALVFrmRakcqKUkgSnywME8AqI0yuMsrZAl1OrVs3fIzWB72JH_bxoKZpxplQmYJI0Ykq3OC9s5XeuqYzbqcJ6C9lelKmowj9rUyLGLrYV495Z8vfyI-jCLAJ8HHV19b93f6n9hPlunZ5</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Lee, Andrew H. 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| subjects | Biopsy Breast Breast cancer Brief Report Endometriosis GATA-3 protein Medicine Medicine & Public Health Mimicry Mitosis Mutation Pathology Tumors |
| title | Malignant phyllodes tumour of the breast mimicking endometriosis |
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