Neurotoxic reactive astrocytes induce cell death via saturated lipids

Astrocytes regulate the response of the central nervous system to disease and injury and have been hypothesized to actively kill neurons in neurodegenerative disease 1 – 6 . Here we report an approach to isolate one component of the long-sought astrocyte-derived toxic factor 5 , 6 . Notably, instead...

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Veröffentlicht in:	Nature (London) 2021-11, Vol.599 (7883), p.102-107
Hauptverfasser:	Guttenplan, Kevin A., Weigel, Maya K., Prakash, Priya, Wijewardhane, Prageeth R., Hasel, Philip, Rufen-Blanchette, Uriel, Münch, Alexandra E., Blum, Jacob A., Fine, Jonathan, Neal, Mikaela C., Bruce, Kimberley D., Gitler, Aaron D., Chopra, Gaurav, Liddelow, Shane A., Barres, Ben A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/2 13/21 13/51 14/63 631/378/1689/364 631/378/2596/1308 64/60 82/58 Animals Apolipoprotein E Apoptosis Astrocytes Astrocytes - chemistry Astrocytes - metabolism Biocompatibility Cell death Cell Death - drug effects Central nervous system Chromatography Culture Media, Conditioned - chemistry Culture Media, Conditioned - toxicity Endoplasmic reticulum Enzymes Fatty Acid Elongases - deficiency Fatty Acid Elongases - genetics Fatty Acid Elongases - metabolism Female Gene Knockout Techniques Humanities and Social Sciences Hypotheses Kinases Lipids Lipids - chemistry Lipids - toxicity Lipoproteins Male Mass spectrometry Membranes Mice Mice, Knockout multidisciplinary Nervous system Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurotoxicity Neurotoxins - chemistry Neurotoxins - toxicity Proteins Science Science (multidisciplinary) Scientific imaging Toxicity Tumor necrosis factor-TNF
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