Solid dispersion of β-lapachone in PVP K30 and PEG 6000 by spray drying technique

Beta-lapachone (βlap) is a naphthoquinone derived from Lapachol, a substance extracted from the Bignoniaceae family of trees, genus Tabebuia; found in the Northern and Northeastern regions of Brazil. βlap shows excellent pharmacological activity as an antiparasitic, antitumor, and anti-inflammatory...

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Veröffentlicht in:	Journal of thermal analysis and calorimetry 2021-12, Vol.146 (6), p.2523-2532
Hauptverfasser:	dos Santos, Klecia M., de Melo Barbosa, Raquel, Meirelles, Lyghia, Vargas, Fernanda Grace A., da Silva Lins, Antônio Claudio, Camara, Celso A., Aragão, Cicero F. S., de Lima Moura, Tulio Flavio, Raffin, Fernanda Nervo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Anticancer properties Bioavailability Chemistry Chemistry and Materials Science Differential scanning calorimetry Dispersions Dissolution Formulations Fourier transforms Infrared spectroscopy Inorganic Chemistry Mathematical models Measurement Science and Instrumentation Microparticles Physical Chemistry Polyethylene glycol Polymer Sciences Polyvinylpyrrolidone Scanning electron microscopy Size distribution Solubility Spray drying X ray powder diffraction
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