Synthesis and characterization of bile acid‐based polymeric micelle as a drug carrier for doxorubicin
In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)‐block‐poly(oligoethylene glycol methacrylate) (PMML‐b‐POEGMA) bearing bile acid moiety is prepared via sequential photo‐initiated free radical polymerizations, and its drug...
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| Veröffentlicht in: | Polymers for advanced technologies 2021-12, Vol.32 (12), p.4860-4868 |
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| container_title | Polymers for advanced technologies |
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| creator | Altinkok, Cagatay Acik, Gokhan Karabulut, Huseyin Riza Ferhat Ciftci, Mustafa Tasdelen, Mehmet Atilla Dag, Aydan |
| description | In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)‐block‐poly(oligoethylene glycol methacrylate) (PMML‐b‐POEGMA) bearing bile acid moiety is prepared via sequential photo‐initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two‐step procedure is applied in the presence of phenylbis (2,4,6‐trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML‐b‐POEGMA) is successfully synthesized by wavelength‐selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML‐b‐POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML‐b‐POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti‐cancer drugs for combination chemotherapy. |
| doi_str_mv | 10.1002/pat.5478 |
| format | Article |
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For this purpose, two‐step procedure is applied in the presence of phenylbis (2,4,6‐trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML‐b‐POEGMA) is successfully synthesized by wavelength‐selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML‐b‐POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML‐b‐POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti‐cancer drugs for combination chemotherapy.</description><identifier>ISSN: 1042-7147</identifier><identifier>EISSN: 1099-1581</identifier><identifier>DOI: 10.1002/pat.5478</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>amphiphilic ; Block copolymers ; Carrying capacity ; Doxorubicin ; Drug carriers ; drug release ; Free radical polymerization ; Free radicals ; lithocholic acid ; Micelles ; Phosphine oxide ; Photopolymerization</subject><ispartof>Polymers for advanced technologies, 2021-12, Vol.32 (12), p.4860-4868</ispartof><rights>2021 John Wiley & Sons Ltd.</rights><rights>2021 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2938-e592ed5eb61388e57838801878f03f4dd32fd35071dacd620e2e0333094c74283</citedby><cites>FETCH-LOGICAL-c2938-e592ed5eb61388e57838801878f03f4dd32fd35071dacd620e2e0333094c74283</cites><orcidid>0000-0002-9501-6296 ; 0000-0002-7012-7029 ; 0000-0002-9427-0508</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpat.5478$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpat.5478$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Altinkok, Cagatay</creatorcontrib><creatorcontrib>Acik, Gokhan</creatorcontrib><creatorcontrib>Karabulut, Huseyin Riza Ferhat</creatorcontrib><creatorcontrib>Ciftci, Mustafa</creatorcontrib><creatorcontrib>Tasdelen, Mehmet Atilla</creatorcontrib><creatorcontrib>Dag, Aydan</creatorcontrib><title>Synthesis and characterization of bile acid‐based polymeric micelle as a drug carrier for doxorubicin</title><title>Polymers for advanced technologies</title><description>In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)‐block‐poly(oligoethylene glycol methacrylate) (PMML‐b‐POEGMA) bearing bile acid moiety is prepared via sequential photo‐initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two‐step procedure is applied in the presence of phenylbis (2,4,6‐trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML‐b‐POEGMA) is successfully synthesized by wavelength‐selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML‐b‐POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML‐b‐POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti‐cancer drugs for combination chemotherapy.</description><subject>amphiphilic</subject><subject>Block copolymers</subject><subject>Carrying capacity</subject><subject>Doxorubicin</subject><subject>Drug carriers</subject><subject>drug release</subject><subject>Free radical polymerization</subject><subject>Free radicals</subject><subject>lithocholic acid</subject><subject>Micelles</subject><subject>Phosphine oxide</subject><subject>Photopolymerization</subject><issn>1042-7147</issn><issn>1099-1581</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKxDAUhoMoOI6CjxBw46Zjbp2ky0G8wYCC4zqkSTqTodPUpEXrykfwGX0SU8etq__A-c5_4APgHKMZRohctaqb5YyLAzDBqCgynAt8OM6MZBwzfgxOYtwilHYFn4D189B0GxtdhKoxUG9UULqzwX2ozvkG-gqWrrZQaWe-P79KFa2Bra-HXWI03Dlt63GdzqEJ_RpqFYKzAVY-QOPffehLp11zCo4qVUd79pdT8HJ7s7q-z5aPdw_Xi2WmSUFFZvOCWJPbco6pEDbnIgXCgosK0YoZQ0llaI44NkqbOUGWWEQpRQXTnBFBp-Bi39sG_9rb2Mmt70OTXkqSuikjhBeJutxTOvgYg61kG9xOhUFiJEeNMmmUo8aEZnv0LWkY_uXk02L1y_8Alpx0pg</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Altinkok, Cagatay</creator><creator>Acik, Gokhan</creator><creator>Karabulut, Huseyin Riza Ferhat</creator><creator>Ciftci, Mustafa</creator><creator>Tasdelen, Mehmet Atilla</creator><creator>Dag, Aydan</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0002-9501-6296</orcidid><orcidid>https://orcid.org/0000-0002-7012-7029</orcidid><orcidid>https://orcid.org/0000-0002-9427-0508</orcidid></search><sort><creationdate>202112</creationdate><title>Synthesis and characterization of bile acid‐based polymeric micelle as a drug carrier for doxorubicin</title><author>Altinkok, Cagatay ; Acik, Gokhan ; Karabulut, Huseyin Riza Ferhat ; Ciftci, Mustafa ; Tasdelen, Mehmet Atilla ; Dag, Aydan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2938-e592ed5eb61388e57838801878f03f4dd32fd35071dacd620e2e0333094c74283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>amphiphilic</topic><topic>Block copolymers</topic><topic>Carrying capacity</topic><topic>Doxorubicin</topic><topic>Drug carriers</topic><topic>drug release</topic><topic>Free radical polymerization</topic><topic>Free radicals</topic><topic>lithocholic acid</topic><topic>Micelles</topic><topic>Phosphine oxide</topic><topic>Photopolymerization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Altinkok, Cagatay</creatorcontrib><creatorcontrib>Acik, Gokhan</creatorcontrib><creatorcontrib>Karabulut, Huseyin Riza Ferhat</creatorcontrib><creatorcontrib>Ciftci, Mustafa</creatorcontrib><creatorcontrib>Tasdelen, Mehmet Atilla</creatorcontrib><creatorcontrib>Dag, Aydan</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Polymers for advanced technologies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altinkok, Cagatay</au><au>Acik, Gokhan</au><au>Karabulut, Huseyin Riza Ferhat</au><au>Ciftci, Mustafa</au><au>Tasdelen, Mehmet Atilla</au><au>Dag, Aydan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and characterization of bile acid‐based polymeric micelle as a drug carrier for doxorubicin</atitle><jtitle>Polymers for advanced technologies</jtitle><date>2021-12</date><risdate>2021</risdate><volume>32</volume><issue>12</issue><spage>4860</spage><epage>4868</epage><pages>4860-4868</pages><issn>1042-7147</issn><eissn>1099-1581</eissn><abstract>In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)‐block‐poly(oligoethylene glycol methacrylate) (PMML‐b‐POEGMA) bearing bile acid moiety is prepared via sequential photo‐initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two‐step procedure is applied in the presence of phenylbis (2,4,6‐trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML‐b‐POEGMA) is successfully synthesized by wavelength‐selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML‐b‐POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. 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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | amphiphilic Block copolymers Carrying capacity Doxorubicin Drug carriers drug release Free radical polymerization Free radicals lithocholic acid Micelles Phosphine oxide Photopolymerization |
| title | Synthesis and characterization of bile acid‐based polymeric micelle as a drug carrier for doxorubicin |
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