Synthesis of a Diapocynin Prodrug for Its Prolonged Release from Zwitterionic Biodegradable Nanoparticles

Today, neurodegenerative diseases are affecting more and more individuals. A typical therapeutic target to treat the progression of the symptoms related to these diseases is the proinflammatory microglia. Diapocynin, the dimeric version of apocynin, is often the drug of choice. However, suitable car...

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Veröffentlicht in:	Macromolecular chemistry and physics 2021-11, Vol.222 (21), p.n/a
Hauptverfasser:	Auriemma, Renato, Sponchioni, Mattia, Capasso Palmiero, Umberto, Manfredini, Nicolò, Razavi Dinani, Fatemeh Sadat, Moscatelli, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	Addition polymerization amyotrophic lateral sclerosis Biodegradability Chain transfer diapocynin drug delivery microglia Nanoparticles polymer nanoparticles Polymerization Ring opening polymerization Signs and symptoms Sustained release Zwitterions
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