Effects of 2,4‐dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy‐related proteins as well as the protective effect of Lycium barbarum polysaccharide in neonatal rats

The pesticide 2,4‐dichlorophenoxyacetic acid (2,4‐D) has neurotoxic effects, but its mechanism is not clear. In this study, a 2,4‐D (75 mg/kg. b.w) exposure model was established in SD rats with colostrum. Lipopolysaccharide (1 mg/kg b.w) was used as the positive control, and Lycium barbarum polysac...

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Veröffentlicht in:	Environmental toxicology 2021-12, Vol.36 (12), p.2454-2466
Hauptverfasser:	Zhou, Jian, Li, Honghui, Wang, Faxuan, Wang, Hengquan, Chai, Ru, Li, Jiangping, Jia, Leina, Wang, Kai, Zhang, Pengju, Zhu, Lingqin, Yang, Huifang
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4‐dichlorophenoxyacetic acid Autophagy Caspase Colostrum Dichlorophenoxyacetic acid Glutathione Glutathione peroxidase Hippocampus Inflammasomes Inflammation Lipopolysaccharides Lycium barbarum Lycium barbarum polysaccharide Malondialdehyde mRNA neonatal rats Neonates Neuroprotection Neurotoxicity NLRP3 inflammasome Oxidative stress Peroxidase Pesticides Phagocytosis Polysaccharides Proteins Pyramidal cells Serum Superoxide dismutase Tumor necrosis factor-α
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