O2‐Assisted Four‐Component Reaction of Vinyl Magnesium Bromide with Chiral N‐tert‐Butanesulfinyl Imines To Form syn‐1,3‐Amino Alcohols

An O2‐assisted, four‐component reaction has been developed to synthesize a wide range of syn‐1,3‐amino alcohols in one step. The reaction proceeds by oxygenation of vinyl magnesium bromide (component‐I) with O2 (component‐II) to give a magnesium enolate of acetaldehyde, which undergoes addition to a...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Angewandte Chemie 2021-11, Vol.133 (46), p.24849-24854
Hauptverfasser:	Wang, Runping, Luo, Jingfan, Zheng, Chunmei, Zhang, Hongyun, Gao, Lu, Song, Zhenlei
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3-amino alcohol Acetaldehyde Alcohols Chemistry Diols Imines Magnesium Magnesium bromides multi-component reaction N-tert-butanesulfinyl imines Oxygenation Piperidine Stereoselectivity vinyl magnesium bromide
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!