Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity

Tumor-associated macrophages (TAMs) display pro-tumorigenic phenotypes for supporting tumor progression in response to microenvironmental cues imposed by tumor and stromal cells. However, the underlying mechanisms by which tumor cells instruct TAM behavior remain elusive. Here, we uncover that tumor...

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Veröffentlicht in:	Nature immunology 2021-11, Vol.22 (11), p.1403-1415
Hauptverfasser:	Di Conza, Giusy, Tsai, Chin-Hsien, Gallart-Ayala, Hector, Yu, Yi-Ru, Franco, Fabien, Zaffalon, Lea, Xie, Xin, Li, Xiaoyun, Xiao, Zhengtao, Raines, Lydia N., Falquet, Maryline, Jalil, Antoine, Locasale, Jason W., Percipalle, Piergiorgio, Masson, David, Huang, Stanley Ching-Cheng, Martinon, Fabio, Ivanisevic, Julijana, Ho, Ping-Chih
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2504/342 631/250/580 Animals Biomedical and Life Sciences Biomedicine Cancer Cell interaction Cell Line, Tumor Cell Survival Cellular signal transduction Cellular stress response Development and progression Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - ultrastructure Endoplasmic Reticulum Stress Genetic aspects Glucosylceramidase - metabolism Health aspects Immunology Infectious Diseases Intracellular Membranes - metabolism Intracellular Membranes - ultrastructure Lecithin Lipid composition Lipids Macrophage Activation Macrophages Melanoma - genetics Melanoma - metabolism Melanoma - ultrastructure Membrane lipids Membrane Lipids - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Oncology, Experimental Phenotype Phenotypes Phosphatidylcholine Phosphorylation Physiological aspects Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - ultrastructure Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Stromal cells Survival Therapeutic targets Tumor cells Tumor Escape Tumor Microenvironment Tumor-Associated Macrophages - metabolism Tumor-Associated Macrophages - ultrastructure Tumors X-Box Binding Protein 1 - genetics X-Box Binding Protein 1 - metabolism
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