18F‐FDG PET/CT use in functional assessment of the testes: A systematic review
Introduction Our study analysed previous studies employing positron emission tomography with co‐registered computer tomography (PET/CT) in andrological patient evaluation and assessed the differences in 2‐[18F]F‐fluoro‐2′‐deoxyglucose (FDG) uptake between three groups: healthy testes, benign and mal...
Gespeichert in:
| Veröffentlicht in: | Andrology (Oxford) 2021-09, Vol.9 (5), p.1410-1421 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1421 |
|---|---|
| container_issue | 5 |
| container_start_page | 1410 |
| container_title | Andrology (Oxford) |
| container_volume | 9 |
| creator | Bochiński, Antoni Sujenthiran, Arunan Al‐Hussini, Mohamed Fruhwirth, Gilbert O. Shabbir, Majed Yap, Tet |
| description | Introduction
Our study analysed previous studies employing positron emission tomography with co‐registered computer tomography (PET/CT) in andrological patient evaluation and assessed the differences in 2‐[18F]F‐fluoro‐2′‐deoxyglucose (FDG) uptake between three groups: healthy testes, benign and malignant testicular pathology.
Methods
Medline and Embase were systematically searched for studies involving FDG‐PET/CT imaging of testes with results expressed as mean standardised uptake value (SUVmean). A one‐way ANOVA was used to compare SUVmean between three groups. All papers assessing andrological parameters were pooled to compare fertility data.
Results
Seventeen studies, including three relating to fertility diagnosis, with a total of 830 patients, were included in the review. One‐way ANOVA showed a statistical difference between mean values of tracer SUVmean in healthy and malignant testes (Dif. = −2.77, 95% CI = −4.32 to 1.21, p |
| doi_str_mv | 10.1111/andr.13042 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_proquest_journals_2586921567</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2586921567</sourcerecordid><originalsourceid>FETCH-LOGICAL-p1912-17da7c7d17570eb67e382c2a8dd26f8b090e79b47f59605996740966486cebcc3</originalsourceid><addsrcrecordid>eNo9kM1Kw0AUhQdRsNRufIIB12lnJsn8uCv9UyhaJK6HyeQGU9qkZhJLdn0En9EncdKKhwP3Wxwuh4PQPSVj6jUxZVaPaUgidoUGjEQiYIqJ63-m6haNnNsSL9mbDdCGyuXP6Xs5X-HNIpnMEtw6wEWJ87a0TVGVZoeNc-DcHsoGVzluPgA34Lwf8RS7ztPeNIXFNXwVcLxDN7nZORj93SF6Xy6S2VOwfl09z6br4EAVZQEVmRFWZFTEgkDKBYSSWWZkljGey5QoAkKlkchjxUmsFBcRUZxHkltIrQ2H6OHy91BXn63vo7dVW_u6TrNYcsVozIVP0UvqWOyg04e62Ju605TofjHdL6bPi-npy_ztTOEvlhtfBA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2586921567</pqid></control><display><type>article</type><title>18F‐FDG PET/CT use in functional assessment of the testes: A systematic review</title><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><creator>Bochiński, Antoni ; Sujenthiran, Arunan ; Al‐Hussini, Mohamed ; Fruhwirth, Gilbert O. ; Shabbir, Majed ; Yap, Tet</creator><creatorcontrib>Bochiński, Antoni ; Sujenthiran, Arunan ; Al‐Hussini, Mohamed ; Fruhwirth, Gilbert O. ; Shabbir, Majed ; Yap, Tet</creatorcontrib><description>Introduction
Our study analysed previous studies employing positron emission tomography with co‐registered computer tomography (PET/CT) in andrological patient evaluation and assessed the differences in 2‐[18F]F‐fluoro‐2′‐deoxyglucose (FDG) uptake between three groups: healthy testes, benign and malignant testicular pathology.
Methods
Medline and Embase were systematically searched for studies involving FDG‐PET/CT imaging of testes with results expressed as mean standardised uptake value (SUVmean). A one‐way ANOVA was used to compare SUVmean between three groups. All papers assessing andrological parameters were pooled to compare fertility data.
Results
Seventeen studies, including three relating to fertility diagnosis, with a total of 830 patients, were included in the review. One‐way ANOVA showed a statistical difference between mean values of tracer SUVmean in healthy and malignant testes (Dif. = −2.77, 95% CI = −4.32 to 1.21, p < 0.01) as well as benign and malignant (Dif. = −2.95, 95% CI = −4.33 to −1.21, p < 0.01) but no difference between healthy and benign (Dif. = 0.19, 95% CI = −0.96 to 1.33, p = 0.90). There is some evidence to suggest that FDG uptake and testicular volume are positively correlated to total sperm count, sperm concentration and sperm motility and that germ cells are likely to account for the majority of testicular FDG accumulation.
Conclusion
Our findings indicate that malignant testicular lesions demonstrate a significantly higher FDG uptake than benign testicular lesions or healthy testes. Some evidence also suggests that FDG‐PET could visualise metabolic activity and thus spermatogenesis; however more studies are required to determine whether FDG‐PET could also be used to diagnose infertility. Further studies should focus on correlating both sex hormone‐serum levels and semen analysis results with imaging data.</description><identifier>ISSN: 2047-2919</identifier><identifier>EISSN: 2047-2927</identifier><identifier>DOI: 10.1111/andr.13042</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>andrology ; FDG ; Fertility ; Infertility ; metabolic imaging ; PET/CT ; Sperm ; Testes ; Tomography</subject><ispartof>Andrology (Oxford), 2021-09, Vol.9 (5), p.1410-1421</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-3420-2447</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fandr.13042$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fandr.13042$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids></links><search><creatorcontrib>Bochiński, Antoni</creatorcontrib><creatorcontrib>Sujenthiran, Arunan</creatorcontrib><creatorcontrib>Al‐Hussini, Mohamed</creatorcontrib><creatorcontrib>Fruhwirth, Gilbert O.</creatorcontrib><creatorcontrib>Shabbir, Majed</creatorcontrib><creatorcontrib>Yap, Tet</creatorcontrib><title>18F‐FDG PET/CT use in functional assessment of the testes: A systematic review</title><title>Andrology (Oxford)</title><description>Introduction
Our study analysed previous studies employing positron emission tomography with co‐registered computer tomography (PET/CT) in andrological patient evaluation and assessed the differences in 2‐[18F]F‐fluoro‐2′‐deoxyglucose (FDG) uptake between three groups: healthy testes, benign and malignant testicular pathology.
Methods
Medline and Embase were systematically searched for studies involving FDG‐PET/CT imaging of testes with results expressed as mean standardised uptake value (SUVmean). A one‐way ANOVA was used to compare SUVmean between three groups. All papers assessing andrological parameters were pooled to compare fertility data.
Results
Seventeen studies, including three relating to fertility diagnosis, with a total of 830 patients, were included in the review. One‐way ANOVA showed a statistical difference between mean values of tracer SUVmean in healthy and malignant testes (Dif. = −2.77, 95% CI = −4.32 to 1.21, p < 0.01) as well as benign and malignant (Dif. = −2.95, 95% CI = −4.33 to −1.21, p < 0.01) but no difference between healthy and benign (Dif. = 0.19, 95% CI = −0.96 to 1.33, p = 0.90). There is some evidence to suggest that FDG uptake and testicular volume are positively correlated to total sperm count, sperm concentration and sperm motility and that germ cells are likely to account for the majority of testicular FDG accumulation.
Conclusion
Our findings indicate that malignant testicular lesions demonstrate a significantly higher FDG uptake than benign testicular lesions or healthy testes. Some evidence also suggests that FDG‐PET could visualise metabolic activity and thus spermatogenesis; however more studies are required to determine whether FDG‐PET could also be used to diagnose infertility. Further studies should focus on correlating both sex hormone‐serum levels and semen analysis results with imaging data.</description><subject>andrology</subject><subject>FDG</subject><subject>Fertility</subject><subject>Infertility</subject><subject>metabolic imaging</subject><subject>PET/CT</subject><subject>Sperm</subject><subject>Testes</subject><subject>Tomography</subject><issn>2047-2919</issn><issn>2047-2927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNo9kM1Kw0AUhQdRsNRufIIB12lnJsn8uCv9UyhaJK6HyeQGU9qkZhJLdn0En9EncdKKhwP3Wxwuh4PQPSVj6jUxZVaPaUgidoUGjEQiYIqJ63-m6haNnNsSL9mbDdCGyuXP6Xs5X-HNIpnMEtw6wEWJ87a0TVGVZoeNc-DcHsoGVzluPgA34Lwf8RS7ztPeNIXFNXwVcLxDN7nZORj93SF6Xy6S2VOwfl09z6br4EAVZQEVmRFWZFTEgkDKBYSSWWZkljGey5QoAkKlkchjxUmsFBcRUZxHkltIrQ2H6OHy91BXn63vo7dVW_u6TrNYcsVozIVP0UvqWOyg04e62Ju605TofjHdL6bPi-npy_ztTOEvlhtfBA</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Bochiński, Antoni</creator><creator>Sujenthiran, Arunan</creator><creator>Al‐Hussini, Mohamed</creator><creator>Fruhwirth, Gilbert O.</creator><creator>Shabbir, Majed</creator><creator>Yap, Tet</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-3420-2447</orcidid></search><sort><creationdate>202109</creationdate><title>18F‐FDG PET/CT use in functional assessment of the testes: A systematic review</title><author>Bochiński, Antoni ; Sujenthiran, Arunan ; Al‐Hussini, Mohamed ; Fruhwirth, Gilbert O. ; Shabbir, Majed ; Yap, Tet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1912-17da7c7d17570eb67e382c2a8dd26f8b090e79b47f59605996740966486cebcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>andrology</topic><topic>FDG</topic><topic>Fertility</topic><topic>Infertility</topic><topic>metabolic imaging</topic><topic>PET/CT</topic><topic>Sperm</topic><topic>Testes</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bochiński, Antoni</creatorcontrib><creatorcontrib>Sujenthiran, Arunan</creatorcontrib><creatorcontrib>Al‐Hussini, Mohamed</creatorcontrib><creatorcontrib>Fruhwirth, Gilbert O.</creatorcontrib><creatorcontrib>Shabbir, Majed</creatorcontrib><creatorcontrib>Yap, Tet</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Andrology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bochiński, Antoni</au><au>Sujenthiran, Arunan</au><au>Al‐Hussini, Mohamed</au><au>Fruhwirth, Gilbert O.</au><au>Shabbir, Majed</au><au>Yap, Tet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>18F‐FDG PET/CT use in functional assessment of the testes: A systematic review</atitle><jtitle>Andrology (Oxford)</jtitle><date>2021-09</date><risdate>2021</risdate><volume>9</volume><issue>5</issue><spage>1410</spage><epage>1421</epage><pages>1410-1421</pages><issn>2047-2919</issn><eissn>2047-2927</eissn><abstract>Introduction
Our study analysed previous studies employing positron emission tomography with co‐registered computer tomography (PET/CT) in andrological patient evaluation and assessed the differences in 2‐[18F]F‐fluoro‐2′‐deoxyglucose (FDG) uptake between three groups: healthy testes, benign and malignant testicular pathology.
Methods
Medline and Embase were systematically searched for studies involving FDG‐PET/CT imaging of testes with results expressed as mean standardised uptake value (SUVmean). A one‐way ANOVA was used to compare SUVmean between three groups. All papers assessing andrological parameters were pooled to compare fertility data.
Results
Seventeen studies, including three relating to fertility diagnosis, with a total of 830 patients, were included in the review. One‐way ANOVA showed a statistical difference between mean values of tracer SUVmean in healthy and malignant testes (Dif. = −2.77, 95% CI = −4.32 to 1.21, p < 0.01) as well as benign and malignant (Dif. = −2.95, 95% CI = −4.33 to −1.21, p < 0.01) but no difference between healthy and benign (Dif. = 0.19, 95% CI = −0.96 to 1.33, p = 0.90). There is some evidence to suggest that FDG uptake and testicular volume are positively correlated to total sperm count, sperm concentration and sperm motility and that germ cells are likely to account for the majority of testicular FDG accumulation.
Conclusion
Our findings indicate that malignant testicular lesions demonstrate a significantly higher FDG uptake than benign testicular lesions or healthy testes. Some evidence also suggests that FDG‐PET could visualise metabolic activity and thus spermatogenesis; however more studies are required to determine whether FDG‐PET could also be used to diagnose infertility. Further studies should focus on correlating both sex hormone‐serum levels and semen analysis results with imaging data.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/andr.13042</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-3420-2447</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2047-2919 |
| ispartof | Andrology (Oxford), 2021-09, Vol.9 (5), p.1410-1421 |
| issn | 2047-2919 2047-2927 |
| language | eng |
| recordid | cdi_proquest_journals_2586921567 |
| source | Wiley Online Library Journals Frontfile Complete; Wiley Free Content |
| subjects | andrology FDG Fertility Infertility metabolic imaging PET/CT Sperm Testes Tomography |
| title | 18F‐FDG PET/CT use in functional assessment of the testes: A systematic review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T00%3A08%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_wiley&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=18F%E2%80%90FDG%20PET/CT%20use%20in%20functional%20assessment%20of%20the%20testes:%20A%20systematic%20review&rft.jtitle=Andrology%20(Oxford)&rft.au=Bochi%C5%84ski,%20Antoni&rft.date=2021-09&rft.volume=9&rft.issue=5&rft.spage=1410&rft.epage=1421&rft.pages=1410-1421&rft.issn=2047-2919&rft.eissn=2047-2927&rft_id=info:doi/10.1111/andr.13042&rft_dat=%3Cproquest_wiley%3E2586921567%3C/proquest_wiley%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2586921567&rft_id=info:pmid/&rfr_iscdi=true |