The impact of bridging therapy prior to CD19‐directed chimeric antigen receptor T‐cell therapy in patients with large B‐cell lymphoma

Summary In the relapsed/refractory setting for treatment of large B‐cell lymphoma (LBCL), chimeric antigen receptor T‐cell (CAR‐T) therapy has emerged as an effective treatment modality. Patients often have aggressive disease that requires prompt treatment in the form of bridging therapy (BT) for di...

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Veröffentlicht in:	British journal of haematology 2021-11, Vol.195 (3), p.405-412
Hauptverfasser:	Lutfi, Forat, Holtzman, Noa G., Kansagra, Ankit J., Mustafa Ali, Moaath, Bukhari, Ali, Yan, Jingsheng, Samanta, Santanu, Gottlieb, David, Kim, Dong W., Matsumoto, Lisa R., Gahres, Natalie, Ruehle, Kathleen, Lee, Seung T., Law, Jennie Y., Kocoglu, Mehmet H., Atanackovic, Djordje, Yared, Jean A., Hardy, Nancy M., Molitoris, Jason, Mohindra, Pranshu, Rapoport, Aaron P., Dahiya, Saurabh
Format:	Artikel
Sprache:	eng
Schlagworte:	adoptive cellular therapies Adrenal Cortex Hormones - therapeutic use Adult Aged Antigens Antigens, CD19 - immunology Antineoplastic Combined Chemotherapy Protocols - therapeutic use B-cell lymphoma Biological Products - therapeutic use bridging therapy CAR‐T therapy CD19 antigen Cell therapy Chimeric antigen receptors Combined Modality Therapy Cyclophosphamide - administration & dosage cytokine release syndrome Cytokine Release Syndrome - etiology Cytokines Female Hematology Humans immune effector cell‐associated neurotoxicity Immunotherapy, Adoptive - adverse effects Kaplan-Meier Estimate Leukapheresis Lymphocyte Depletion Lymphocytes T Lymphoma Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - etiology Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - therapy Male Middle Aged Neurotoxicity Pancytopenia - chemically induced Patients Progression-Free Survival Receptors, Antigen, T-Cell - therapeutic use Retrospective Studies Salvage Therapy Vidarabine - administration & dosage Vidarabine - analogs & derivatives
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