The Effects Of Feeding Triacylglycerols On Milk Fat Composition, Lipogenesis And Polymer-Protomer Transition Of Acetyl-Coa Carboxylase In Rat Mammary Gland
Diets rich in fats produce large quantities of milk with high lipid concentrations, which may be important for the growth of neonates. The present study investigates the effect of different fat enriched diets on mammary gland lipogenesis in lactating rats. Rats were fed for 6 weeks during pregnancy...
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| Veröffentlicht in: | African journal of food, agriculture, nutrition, and development : AJFAND agriculture, nutrition, and development : AJFAND, 2009-06, Vol.9 (4), p.1060-1075 |
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| container_title | African journal of food, agriculture, nutrition, and development : AJFAND |
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| creator | Oben, JE Ngondi, JL Agbor, GA Enonchong, E |
| description | Diets rich in fats produce large quantities of milk with high lipid
concentrations, which may be important for the growth of neonates. The
present study investigates the effect of different fat enriched diets
on mammary gland lipogenesis in lactating rats. Rats were fed for 6
weeks during pregnancy through to mid-lactation with diets containing
chow supplemented with 20% (w/w) coconut oil, olive oil or corn oil.
The control animals were fed with a low fat (0.5%, w/w) diet, or with
chow (6.8%, w/w fat). Rats fed either the 20% (w/w) olive
oil-supplemented diet or the 20% (w/w) corn oil-supplemented diet
produced milk with significantly lower total fat concentrations
(p |
| format | Article |
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concentrations, which may be important for the growth of neonates. The
present study investigates the effect of different fat enriched diets
on mammary gland lipogenesis in lactating rats. Rats were fed for 6
weeks during pregnancy through to mid-lactation with diets containing
chow supplemented with 20% (w/w) coconut oil, olive oil or corn oil.
The control animals were fed with a low fat (0.5%, w/w) diet, or with
chow (6.8%, w/w fat). Rats fed either the 20% (w/w) olive
oil-supplemented diet or the 20% (w/w) corn oil-supplemented diet
produced milk with significantly lower total fat concentrations
(p<0.05) than rats fed the low-fat (0.5% (w/w) corn oil) control
diet or with chow (6.8% (w/w) fat. Rats on the olive oil- and corn
oil-supplemented diets produced milk that had significantly lower
concentrations of total fat and of C8:0 - C18:0 fatty acids and higher
concentrations of C18:1 - C18:3 acids compared to the low-fat diet,
chow, or the coconut oil-supplemented diets. Compared with the low-fat
control diet, all the other dietary regimes suppressed overall fatty
acid synthesis in both the lactating mammary gland and liver, with the
highest suppression being produced by the olive oil- and corn
oil-supplemented diets on mammary fatty acid synthesis. Measurements of
the total activity in the mammary gland of the rate-limiting enzyme,
acetyl-CoA carboxylase, and of the proportions of the polymeric
(active) and protomeric (inactive) forms of this enzyme, showed that
the total activity decreased in parallel with the overall rate of fatty
acid synthesis. This trend was, however, not noticed for fatty acid
synthetase (another lipogenic enzyme). By contrast, a constant
proportion of polymeric to protomeric forms was maintained at
mid-lactation irrespective of the diet, indicating a possible role of
prolactin in mammary gland acetyl-CoA carboxylase polymerization. This
study, therefore, showed that the fatty acid composition of the diet as
well as hormones involved in lactation may affect mammary gland and
liver fatty acid synthesis, through a modification of the rate limiting
enzyme of fatty acid synthesis - acetyl-CoA carboxylase.</description><identifier>ISSN: 1684-5358</identifier><identifier>EISSN: 1684-5374</identifier><language>eng</language><publisher>Nairobi: Rural Outreach Program</publisher><subject>Acetyl-CoA carboxylase, milk fat, lipogenesis ; Chemical properties ; Fatty acids ; Health and Medicine ; Mammary glands ; Milk ; Nutrition ; Nutritional aspects ; Oils & fats ; Properties ; Rodents ; Science and Technology ; Scientific research ; Synthesis ; Triglycerides</subject><ispartof>African journal of food, agriculture, nutrition, and development : AJFAND, 2009-06, Vol.9 (4), p.1060-1075</ispartof><rights>Copyright 2009 - Rural Outreach Program</rights><rights>COPYRIGHT 2009 Rural Outreach Program</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,79175</link.rule.ids></links><search><creatorcontrib>Oben, JE</creatorcontrib><creatorcontrib>Ngondi, JL</creatorcontrib><creatorcontrib>Agbor, GA</creatorcontrib><creatorcontrib>Enonchong, E</creatorcontrib><title>The Effects Of Feeding Triacylglycerols On Milk Fat Composition, Lipogenesis And Polymer-Protomer Transition Of Acetyl-Coa Carboxylase In Rat Mammary Gland</title><title>African journal of food, agriculture, nutrition, and development : AJFAND</title><description>Diets rich in fats produce large quantities of milk with high lipid
concentrations, which may be important for the growth of neonates. The
present study investigates the effect of different fat enriched diets
on mammary gland lipogenesis in lactating rats. Rats were fed for 6
weeks during pregnancy through to mid-lactation with diets containing
chow supplemented with 20% (w/w) coconut oil, olive oil or corn oil.
The control animals were fed with a low fat (0.5%, w/w) diet, or with
chow (6.8%, w/w fat). Rats fed either the 20% (w/w) olive
oil-supplemented diet or the 20% (w/w) corn oil-supplemented diet
produced milk with significantly lower total fat concentrations
(p<0.05) than rats fed the low-fat (0.5% (w/w) corn oil) control
diet or with chow (6.8% (w/w) fat. Rats on the olive oil- and corn
oil-supplemented diets produced milk that had significantly lower
concentrations of total fat and of C8:0 - C18:0 fatty acids and higher
concentrations of C18:1 - C18:3 acids compared to the low-fat diet,
chow, or the coconut oil-supplemented diets. Compared with the low-fat
control diet, all the other dietary regimes suppressed overall fatty
acid synthesis in both the lactating mammary gland and liver, with the
highest suppression being produced by the olive oil- and corn
oil-supplemented diets on mammary fatty acid synthesis. Measurements of
the total activity in the mammary gland of the rate-limiting enzyme,
acetyl-CoA carboxylase, and of the proportions of the polymeric
(active) and protomeric (inactive) forms of this enzyme, showed that
the total activity decreased in parallel with the overall rate of fatty
acid synthesis. This trend was, however, not noticed for fatty acid
synthetase (another lipogenic enzyme). By contrast, a constant
proportion of polymeric to protomeric forms was maintained at
mid-lactation irrespective of the diet, indicating a possible role of
prolactin in mammary gland acetyl-CoA carboxylase polymerization. This
study, therefore, showed that the fatty acid composition of the diet as
well as hormones involved in lactation may affect mammary gland and
liver fatty acid synthesis, through a modification of the rate limiting
enzyme of fatty acid synthesis - acetyl-CoA carboxylase.</description><subject>Acetyl-CoA carboxylase, milk fat, lipogenesis</subject><subject>Chemical properties</subject><subject>Fatty acids</subject><subject>Health and Medicine</subject><subject>Mammary glands</subject><subject>Milk</subject><subject>Nutrition</subject><subject>Nutritional aspects</subject><subject>Oils & fats</subject><subject>Properties</subject><subject>Rodents</subject><subject>Science and Technology</subject><subject>Scientific research</subject><subject>Synthesis</subject><subject>Triglycerides</subject><issn>1684-5358</issn><issn>1684-5374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>N95</sourceid><sourceid>KPI</sourceid><recordid>eNqNkttqGzEQhpfSQFM37yDoVSFbZB32cGmWODWxiSkOuVwk7exGqVZyJRmyz9KXrYyb0oAvisRoGH3zj8TMu-xyXlQs57Rk7__6vPqQfQzhGWPGecEus1-7J0A3fQ8qBnTfoyVAp-2Adl4LNZnBTAq8M-nOoo02P9BSRNS4ce-CjtrZa7TWezeAhaADWtgObZ2ZRvD51rvokpOkhD3BxwILBXEyeeMEaoSX7mUyIgBaWfQ9KW_EOAo_oVsjbPcpu-iFCXD155xlD8ubXfMtX9_frprFOpeE1WUuJYWKEExxTcuirIUimFAFoGRRsIKRueC4k6WSXKpeSTLnUsypqgrCoOwYnWWfT7p7734eIMT22R28TSVbwqukiGlZJio_UYMw0Grbu-iFOv7cC-Ms9DqFFwQXtOYs2Vn29QyfVgejVmcTvrxJSEyElziIQwjt3Xb13-xq8_iWvf6HlYegU7OSCXp4iuGUcu7dUjuT0Hbv9bEnrUoj0b4GbZc2rtMY0d-i2MGB</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Oben, JE</creator><creator>Ngondi, JL</creator><creator>Agbor, GA</creator><creator>Enonchong, E</creator><general>Rural Outreach Program</general><scope>RBI</scope><scope>N95</scope><scope>IMW</scope><scope>KPI</scope></search><sort><creationdate>20090601</creationdate><title>The Effects Of Feeding Triacylglycerols On Milk Fat Composition, Lipogenesis And Polymer-Protomer Transition Of Acetyl-Coa Carboxylase In Rat Mammary Gland</title><author>Oben, JE ; Ngondi, JL ; Agbor, GA ; Enonchong, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2497-bb3e822030937679ac2023ceecb6646421a50db7cb5bcfcb215ba13c8624e7d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acetyl-CoA carboxylase, milk fat, lipogenesis</topic><topic>Chemical properties</topic><topic>Fatty acids</topic><topic>Health and Medicine</topic><topic>Mammary glands</topic><topic>Milk</topic><topic>Nutrition</topic><topic>Nutritional aspects</topic><topic>Oils & fats</topic><topic>Properties</topic><topic>Rodents</topic><topic>Science and Technology</topic><topic>Scientific research</topic><topic>Synthesis</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oben, JE</creatorcontrib><creatorcontrib>Ngondi, JL</creatorcontrib><creatorcontrib>Agbor, GA</creatorcontrib><creatorcontrib>Enonchong, E</creatorcontrib><collection>Bioline International</collection><collection>Gale Business: Insights</collection><collection>Gale In Context: World History</collection><collection>Gale In Context: Global Issues</collection><jtitle>African journal of food, agriculture, nutrition, and development : AJFAND</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oben, JE</au><au>Ngondi, JL</au><au>Agbor, GA</au><au>Enonchong, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects Of Feeding Triacylglycerols On Milk Fat Composition, Lipogenesis And Polymer-Protomer Transition Of Acetyl-Coa Carboxylase In Rat Mammary Gland</atitle><jtitle>African journal of food, agriculture, nutrition, and development : AJFAND</jtitle><date>2009-06-01</date><risdate>2009</risdate><volume>9</volume><issue>4</issue><spage>1060</spage><epage>1075</epage><pages>1060-1075</pages><issn>1684-5358</issn><eissn>1684-5374</eissn><abstract>Diets rich in fats produce large quantities of milk with high lipid
concentrations, which may be important for the growth of neonates. The
present study investigates the effect of different fat enriched diets
on mammary gland lipogenesis in lactating rats. Rats were fed for 6
weeks during pregnancy through to mid-lactation with diets containing
chow supplemented with 20% (w/w) coconut oil, olive oil or corn oil.
The control animals were fed with a low fat (0.5%, w/w) diet, or with
chow (6.8%, w/w fat). Rats fed either the 20% (w/w) olive
oil-supplemented diet or the 20% (w/w) corn oil-supplemented diet
produced milk with significantly lower total fat concentrations
(p<0.05) than rats fed the low-fat (0.5% (w/w) corn oil) control
diet or with chow (6.8% (w/w) fat. Rats on the olive oil- and corn
oil-supplemented diets produced milk that had significantly lower
concentrations of total fat and of C8:0 - C18:0 fatty acids and higher
concentrations of C18:1 - C18:3 acids compared to the low-fat diet,
chow, or the coconut oil-supplemented diets. Compared with the low-fat
control diet, all the other dietary regimes suppressed overall fatty
acid synthesis in both the lactating mammary gland and liver, with the
highest suppression being produced by the olive oil- and corn
oil-supplemented diets on mammary fatty acid synthesis. Measurements of
the total activity in the mammary gland of the rate-limiting enzyme,
acetyl-CoA carboxylase, and of the proportions of the polymeric
(active) and protomeric (inactive) forms of this enzyme, showed that
the total activity decreased in parallel with the overall rate of fatty
acid synthesis. This trend was, however, not noticed for fatty acid
synthetase (another lipogenic enzyme). By contrast, a constant
proportion of polymeric to protomeric forms was maintained at
mid-lactation irrespective of the diet, indicating a possible role of
prolactin in mammary gland acetyl-CoA carboxylase polymerization. This
study, therefore, showed that the fatty acid composition of the diet as
well as hormones involved in lactation may affect mammary gland and
liver fatty acid synthesis, through a modification of the rate limiting
enzyme of fatty acid synthesis - acetyl-CoA carboxylase.</abstract><cop>Nairobi</cop><pub>Rural Outreach Program</pub><tpages>16</tpages></addata></record> |
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| issn | 1684-5358 1684-5374 |
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| source | DOAJ Directory of Open Access Journals; Bioline International; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acetyl-CoA carboxylase, milk fat, lipogenesis Chemical properties Fatty acids Health and Medicine Mammary glands Milk Nutrition Nutritional aspects Oils & fats Properties Rodents Science and Technology Scientific research Synthesis Triglycerides |
| title | The Effects Of Feeding Triacylglycerols On Milk Fat Composition, Lipogenesis And Polymer-Protomer Transition Of Acetyl-Coa Carboxylase In Rat Mammary Gland |
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