Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles
Different phosphates and phosphonates have shown excellent coating ability toward magnetic nanoparticles, improving their stability and biocompatibility which enables their biomedical application. The magnetic hyperthermia efficiency of phosphates (IDP and IHP) and phosphonates (MDP and HEDP) coated...
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| Veröffentlicht in: | Journal of inorganic and organometallic polymers and materials 2021-11, Vol.31 (11), p.4426-4433 |
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| container_title | Journal of inorganic and organometallic polymers and materials |
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| creator | Radović, Magdalena Mirković, Marija Nikolić, Aleksandar S. Kuraica, Milorad Iskrenović, Predrag Milanović, Zorana Vranješ-Đurić, Sanja Perić, Marko |
| description | Different phosphates and phosphonates have shown excellent coating ability toward magnetic nanoparticles, improving their stability and biocompatibility which enables their biomedical application. The magnetic hyperthermia efficiency of phosphates (IDP and IHP) and phosphonates (MDP and HEDP) coated Fe
3
O
4
magnetic nanoparticles (MNPs) were evaluated in an alternating magnetic field. For a deeper understanding of hyperthermia, the behavior of investigated MNPs in the non-alternating magnetic field was monitored by measuring the transparency of the sample. To investigate their theranostic potential coated Fe
3
O
4
-MNPs were radiolabeled with radionuclide
177
Lu. Phosphate coated MNPs were radiolabeled in high radiolabeling yield (> 99%) while phosphonate coated MNPs reached maximum radiolabeling yield of 78%. Regardless lower radiolabeling yield both radiolabeled phosphonate MNPs may be further purified reaching radiochemical purity of more than 95%. In vitro stabile radiolabeled nanoparticles in saline and HSA were obtained. The high heating ability of phosphates and phosphonates coated MNPs as
sine qua non
for efficient in vivo hyperthermia treatment and satisfactory radiolabeling yield justifies their further research in order to develop new theranostic agents. |
| doi_str_mv | 10.1007/s10904-021-02059-1 |
| format | Article |
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3
O
4
magnetic nanoparticles (MNPs) were evaluated in an alternating magnetic field. For a deeper understanding of hyperthermia, the behavior of investigated MNPs in the non-alternating magnetic field was monitored by measuring the transparency of the sample. To investigate their theranostic potential coated Fe
3
O
4
-MNPs were radiolabeled with radionuclide
177
Lu. Phosphate coated MNPs were radiolabeled in high radiolabeling yield (> 99%) while phosphonate coated MNPs reached maximum radiolabeling yield of 78%. Regardless lower radiolabeling yield both radiolabeled phosphonate MNPs may be further purified reaching radiochemical purity of more than 95%. In vitro stabile radiolabeled nanoparticles in saline and HSA were obtained. The high heating ability of phosphates and phosphonates coated MNPs as
sine qua non
for efficient in vivo hyperthermia treatment and satisfactory radiolabeling yield justifies their further research in order to develop new theranostic agents.</description><identifier>ISSN: 1574-1443</identifier><identifier>EISSN: 1574-1451</identifier><identifier>DOI: 10.1007/s10904-021-02059-1</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biocompatibility ; Biomedical materials ; Chemistry ; Chemistry and Materials Science ; Fever ; Heating ; Hyperthermia ; Inorganic Chemistry ; Iron oxides ; Magnetic fields ; Magnetic properties ; Nanoparticles ; Organic Chemistry ; Phosphates ; Phosphonates ; Polymer Sciences ; Radiochemistry ; Radioisotopes ; Radiolabelling</subject><ispartof>Journal of inorganic and organometallic polymers and materials, 2021-11, Vol.31 (11), p.4426-4433</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-9b603bf5cea23bb29952b279ff9de209087db0ee59ffe1e82748a3af33ba891c3</citedby><cites>FETCH-LOGICAL-c363t-9b603bf5cea23bb29952b279ff9de209087db0ee59ffe1e82748a3af33ba891c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10904-021-02059-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10904-021-02059-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Radović, Magdalena</creatorcontrib><creatorcontrib>Mirković, Marija</creatorcontrib><creatorcontrib>Nikolić, Aleksandar S.</creatorcontrib><creatorcontrib>Kuraica, Milorad</creatorcontrib><creatorcontrib>Iskrenović, Predrag</creatorcontrib><creatorcontrib>Milanović, Zorana</creatorcontrib><creatorcontrib>Vranješ-Đurić, Sanja</creatorcontrib><creatorcontrib>Perić, Marko</creatorcontrib><title>Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles</title><title>Journal of inorganic and organometallic polymers and materials</title><addtitle>J Inorg Organomet Polym</addtitle><description>Different phosphates and phosphonates have shown excellent coating ability toward magnetic nanoparticles, improving their stability and biocompatibility which enables their biomedical application. The magnetic hyperthermia efficiency of phosphates (IDP and IHP) and phosphonates (MDP and HEDP) coated Fe
3
O
4
magnetic nanoparticles (MNPs) were evaluated in an alternating magnetic field. For a deeper understanding of hyperthermia, the behavior of investigated MNPs in the non-alternating magnetic field was monitored by measuring the transparency of the sample. To investigate their theranostic potential coated Fe
3
O
4
-MNPs were radiolabeled with radionuclide
177
Lu. Phosphate coated MNPs were radiolabeled in high radiolabeling yield (> 99%) while phosphonate coated MNPs reached maximum radiolabeling yield of 78%. Regardless lower radiolabeling yield both radiolabeled phosphonate MNPs may be further purified reaching radiochemical purity of more than 95%. In vitro stabile radiolabeled nanoparticles in saline and HSA were obtained. The high heating ability of phosphates and phosphonates coated MNPs as
sine qua non
for efficient in vivo hyperthermia treatment and satisfactory radiolabeling yield justifies their further research in order to develop new theranostic agents.</description><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Fever</subject><subject>Heating</subject><subject>Hyperthermia</subject><subject>Inorganic Chemistry</subject><subject>Iron oxides</subject><subject>Magnetic fields</subject><subject>Magnetic properties</subject><subject>Nanoparticles</subject><subject>Organic Chemistry</subject><subject>Phosphates</subject><subject>Phosphonates</subject><subject>Polymer Sciences</subject><subject>Radiochemistry</subject><subject>Radioisotopes</subject><subject>Radiolabelling</subject><issn>1574-1443</issn><issn>1574-1451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kclO5DAQhiMEEusLcLLEOYyXuBMfUUPTI7EJwdmqJJVuo7QdbPeBt-EtuPNk40wQ3DiUa9H_laX6s-yU0XNGafknMKpokVPOUlCpcraTHTBZFjkrJNv9rguxnx2G8EKpqKhkB9nHkwcbNiZGsA2SW4Sw9bhBGwMxltw5m0Mf0VuIxq7ILawsRtOQhcG-JRDII_YG6n5E49q1pHOeXGIiNsaOhOvIEif4wbsBfTQYxunD2oVhDREJ2Parc3bs5y69LVmguC8-37-_vAPrBkh802M4zvY66AOefOWj7Hlx9TRf5jf313_nFzd5I2Yi5qqeUVF3skHgoq65UpLXvFRdp1rk6WZV2dYUUaYJMqx4WVQgoBOihkqxRhxlZ9PewbvXLYaoX9w2XaMPmstKqmLGRZFUfFI13oXgsdODNxvwb5pRPRqkJ4N0Mkj_N0izBIkJCklsV-h_Vv9C_QP5p5gb</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Radović, Magdalena</creator><creator>Mirković, Marija</creator><creator>Nikolić, Aleksandar S.</creator><creator>Kuraica, Milorad</creator><creator>Iskrenović, Predrag</creator><creator>Milanović, Zorana</creator><creator>Vranješ-Đurić, Sanja</creator><creator>Perić, Marko</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20211101</creationdate><title>Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles</title><author>Radović, Magdalena ; Mirković, Marija ; Nikolić, Aleksandar S. ; Kuraica, Milorad ; Iskrenović, Predrag ; Milanović, Zorana ; Vranješ-Đurić, Sanja ; Perić, Marko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-9b603bf5cea23bb29952b279ff9de209087db0ee59ffe1e82748a3af33ba891c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Fever</topic><topic>Heating</topic><topic>Hyperthermia</topic><topic>Inorganic Chemistry</topic><topic>Iron oxides</topic><topic>Magnetic fields</topic><topic>Magnetic properties</topic><topic>Nanoparticles</topic><topic>Organic Chemistry</topic><topic>Phosphates</topic><topic>Phosphonates</topic><topic>Polymer Sciences</topic><topic>Radiochemistry</topic><topic>Radioisotopes</topic><topic>Radiolabelling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radović, Magdalena</creatorcontrib><creatorcontrib>Mirković, Marija</creatorcontrib><creatorcontrib>Nikolić, Aleksandar S.</creatorcontrib><creatorcontrib>Kuraica, Milorad</creatorcontrib><creatorcontrib>Iskrenović, Predrag</creatorcontrib><creatorcontrib>Milanović, Zorana</creatorcontrib><creatorcontrib>Vranješ-Đurić, Sanja</creatorcontrib><creatorcontrib>Perić, Marko</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of inorganic and organometallic polymers and materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radović, Magdalena</au><au>Mirković, Marija</au><au>Nikolić, Aleksandar S.</au><au>Kuraica, Milorad</au><au>Iskrenović, Predrag</au><au>Milanović, Zorana</au><au>Vranješ-Đurić, Sanja</au><au>Perić, Marko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles</atitle><jtitle>Journal of inorganic and organometallic polymers and materials</jtitle><stitle>J Inorg Organomet Polym</stitle><date>2021-11-01</date><risdate>2021</risdate><volume>31</volume><issue>11</issue><spage>4426</spage><epage>4433</epage><pages>4426-4433</pages><issn>1574-1443</issn><eissn>1574-1451</eissn><abstract>Different phosphates and phosphonates have shown excellent coating ability toward magnetic nanoparticles, improving their stability and biocompatibility which enables their biomedical application. The magnetic hyperthermia efficiency of phosphates (IDP and IHP) and phosphonates (MDP and HEDP) coated Fe
3
O
4
magnetic nanoparticles (MNPs) were evaluated in an alternating magnetic field. For a deeper understanding of hyperthermia, the behavior of investigated MNPs in the non-alternating magnetic field was monitored by measuring the transparency of the sample. To investigate their theranostic potential coated Fe
3
O
4
-MNPs were radiolabeled with radionuclide
177
Lu. Phosphate coated MNPs were radiolabeled in high radiolabeling yield (> 99%) while phosphonate coated MNPs reached maximum radiolabeling yield of 78%. Regardless lower radiolabeling yield both radiolabeled phosphonate MNPs may be further purified reaching radiochemical purity of more than 95%. In vitro stabile radiolabeled nanoparticles in saline and HSA were obtained. The high heating ability of phosphates and phosphonates coated MNPs as
sine qua non
for efficient in vivo hyperthermia treatment and satisfactory radiolabeling yield justifies their further research in order to develop new theranostic agents.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10904-021-02059-1</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biocompatibility Biomedical materials Chemistry Chemistry and Materials Science Fever Heating Hyperthermia Inorganic Chemistry Iron oxides Magnetic fields Magnetic properties Nanoparticles Organic Chemistry Phosphates Phosphonates Polymer Sciences Radiochemistry Radioisotopes Radiolabelling |
| title | Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles |
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