DESIGN AND SYNTHESIS OF NOVEL PYRIMIDINE ANALOGS AS ANTI-TUBERCULAR AGENTS TARGETING THYMIDINE KINASE DOMAIN

The inhibition of the enzyme TMP kinase (TMPKmt), is hypothesized as a significant therapy for tuberculosis. A series of designed pyrimidines were synthesized to inhibit the enzyme TMPKmt and evaluated for their enzyme-ligand interactions, antitubercular, physiochemical and ADMET properties. The pyr...

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Veröffentlicht in:	Journal of microbiology, biotechnology and food sciences biotechnology and food sciences, 2021-10, Vol.11 (2), p.e1744
Hauptverfasser:	James, Jainey P., Mathew, Jane B, Ishwar, Bhat K., Kumar, Pankaj, Aiswarya, T.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioavailability Enzymes Guanidine Kinases Molecular docking Molecular interactions Physiochemistry Pyrimidines Spectral analysis Spectrum analysis Thymidine Thymidine kinase Tuberculosis
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