Improved gut microbiota features after the resolution of SARS-CoV-2 infection
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a tropism for the gastrointestinal tract and several studies have shown an alteration of the gut microbiota in hospitalized infected patients. However, long-term data on microbiota changes after recovery are lacking. Met...
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| Veröffentlicht in: | Gut pathogens 2021-10, Vol.13 (1), p.1-62, Article 62 |
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| creator | De Maio, Flavio Ianiro, Gianluca Coppola, Gaetano Santopaolo, Francesco Abbate, Valeria Bianco, Delia Mercedes Del Zompo, Fabio De Matteis, Giuseppe Leo, Massimo Nesci, Antonio Nicoletti, Alberto Pompili, Maurizio Cammarota, Giovanni Posteraro, Brunella Sanguinetti, Maurizio Gasbarrini, Antonio Ponziani, Francesca Romana |
| description | Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a tropism for the gastrointestinal tract and several studies have shown an alteration of the gut microbiota in hospitalized infected patients. However, long-term data on microbiota changes after recovery are lacking. Methods We enrolled 30 patients hospitalized for SARS-CoV-2-related pneumonia. Their gut microbiota was analyzed within 48 h from the admission and compared with (1) that of other patients admitted for suspected bacterial pneumonia (control group) (2) that obtained from the same subject 6 months after nasopharyngeal swab negativization. Results Gut microbiota alpha-diversity increased 6 months after the resolution of SARS-CoV-2 infection. Bacteroidetes relative abundance was higher (approximate to 36.8%) in patients with SARS-CoV-2, and declined to 18.7% when SARS-CoV-2 infection resolved (p = 0.004). Conversely, Firmicutes were prevalent (approximate to 75%) in controls and in samples collected after SARS-CoV-2 infection resolution (p = 0.001). Ruminococcaceae, Lachnospiraceae and Blautia increased after SARS-CoV-2 infection resolution, rebalancing the gut microbiota composition. Conclusion SARS-CoV-2 infection is associated with changes in the gut microbiome, which tend to be reversed in long-term period. |
| doi_str_mv | 10.1186/s13099-021-00459-9 |
| format | Article |
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However, long-term data on microbiota changes after recovery are lacking. Methods We enrolled 30 patients hospitalized for SARS-CoV-2-related pneumonia. Their gut microbiota was analyzed within 48 h from the admission and compared with (1) that of other patients admitted for suspected bacterial pneumonia (control group) (2) that obtained from the same subject 6 months after nasopharyngeal swab negativization. Results Gut microbiota alpha-diversity increased 6 months after the resolution of SARS-CoV-2 infection. Bacteroidetes relative abundance was higher (approximate to 36.8%) in patients with SARS-CoV-2, and declined to 18.7% when SARS-CoV-2 infection resolved (p = 0.004). Conversely, Firmicutes were prevalent (approximate to 75%) in controls and in samples collected after SARS-CoV-2 infection resolution (p = 0.001). Ruminococcaceae, Lachnospiraceae and Blautia increased after SARS-CoV-2 infection resolution, rebalancing the gut microbiota composition. Conclusion SARS-CoV-2 infection is associated with changes in the gut microbiome, which tend to be reversed in long-term period.</description><identifier>ISSN: 1757-4749</identifier><identifier>EISSN: 1757-4749</identifier><identifier>DOI: 10.1186/s13099-021-00459-9</identifier><identifier>PMID: 34656179</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject>Antibiotics ; Biological diversity ; Comparative analysis ; Coronaviruses ; COVID-19 ; Cytokines ; Digestive system ; Discriminant analysis ; Gastroenterology ; Gastroenterology & Hepatology ; Gastrointestinal system ; Gastrointestinal tract ; Gut microbiota ; Health aspects ; Infections ; Intestinal microflora ; Letter to the Editor ; Life Sciences & Biomedicine ; Microbiology ; Microbiomes ; Microbiota ; Microbiota (Symbiotic organisms) ; Pneumonia ; SARS-CoV-2 ; Science & Technology ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Systematic review ; Tropism</subject><ispartof>Gut pathogens, 2021-10, Vol.13 (1), p.1-62, Article 62</ispartof><rights>COPYRIGHT 2021 BioMed Central Ltd.</rights><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>12</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000707699700001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c609t-6ab6a663e7afb6e790b49f8e728526e80c8c89f7cc79596af89ab00cf1c5ff203</citedby><cites>FETCH-LOGICAL-c609t-6ab6a663e7afb6e790b49f8e728526e80c8c89f7cc79596af89ab00cf1c5ff203</cites><orcidid>0000-0001-6199-6372 ; 0000-0002-9780-7059 ; 0000-0002-5924-6238</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520333/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520333/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,39263,53796,53798</link.rule.ids></links><search><creatorcontrib>De Maio, Flavio</creatorcontrib><creatorcontrib>Ianiro, Gianluca</creatorcontrib><creatorcontrib>Coppola, Gaetano</creatorcontrib><creatorcontrib>Santopaolo, Francesco</creatorcontrib><creatorcontrib>Abbate, Valeria</creatorcontrib><creatorcontrib>Bianco, Delia Mercedes</creatorcontrib><creatorcontrib>Del Zompo, Fabio</creatorcontrib><creatorcontrib>De Matteis, Giuseppe</creatorcontrib><creatorcontrib>Leo, Massimo</creatorcontrib><creatorcontrib>Nesci, Antonio</creatorcontrib><creatorcontrib>Nicoletti, Alberto</creatorcontrib><creatorcontrib>Pompili, Maurizio</creatorcontrib><creatorcontrib>Cammarota, Giovanni</creatorcontrib><creatorcontrib>Posteraro, Brunella</creatorcontrib><creatorcontrib>Sanguinetti, Maurizio</creatorcontrib><creatorcontrib>Gasbarrini, Antonio</creatorcontrib><creatorcontrib>Ponziani, Francesca Romana</creatorcontrib><title>Improved gut microbiota features after the resolution of SARS-CoV-2 infection</title><title>Gut pathogens</title><addtitle>GUT PATHOG</addtitle><description>Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a tropism for the gastrointestinal tract and several studies have shown an alteration of the gut microbiota in hospitalized infected patients. However, long-term data on microbiota changes after recovery are lacking. Methods We enrolled 30 patients hospitalized for SARS-CoV-2-related pneumonia. Their gut microbiota was analyzed within 48 h from the admission and compared with (1) that of other patients admitted for suspected bacterial pneumonia (control group) (2) that obtained from the same subject 6 months after nasopharyngeal swab negativization. Results Gut microbiota alpha-diversity increased 6 months after the resolution of SARS-CoV-2 infection. Bacteroidetes relative abundance was higher (approximate to 36.8%) in patients with SARS-CoV-2, and declined to 18.7% when SARS-CoV-2 infection resolved (p = 0.004). Conversely, Firmicutes were prevalent (approximate to 75%) in controls and in samples collected after SARS-CoV-2 infection resolution (p = 0.001). Ruminococcaceae, Lachnospiraceae and Blautia increased after SARS-CoV-2 infection resolution, rebalancing the gut microbiota composition. Conclusion SARS-CoV-2 infection is associated with changes in the gut microbiome, which tend to be reversed in long-term period.</description><subject>Antibiotics</subject><subject>Biological diversity</subject><subject>Comparative analysis</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cytokines</subject><subject>Digestive system</subject><subject>Discriminant analysis</subject><subject>Gastroenterology</subject><subject>Gastroenterology & Hepatology</subject><subject>Gastrointestinal system</subject><subject>Gastrointestinal tract</subject><subject>Gut microbiota</subject><subject>Health aspects</subject><subject>Infections</subject><subject>Intestinal microflora</subject><subject>Letter to the Editor</subject><subject>Life Sciences & Biomedicine</subject><subject>Microbiology</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Pneumonia</subject><subject>SARS-CoV-2</subject><subject>Science & Technology</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Systematic 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Gianluca ; Coppola, Gaetano ; Santopaolo, Francesco ; Abbate, Valeria ; Bianco, Delia Mercedes ; Del Zompo, Fabio ; De Matteis, Giuseppe ; Leo, Massimo ; Nesci, Antonio ; Nicoletti, Alberto ; Pompili, Maurizio ; Cammarota, Giovanni ; Posteraro, Brunella ; Sanguinetti, Maurizio ; Gasbarrini, Antonio ; Ponziani, Francesca Romana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-6ab6a663e7afb6e790b49f8e728526e80c8c89f7cc79596af89ab00cf1c5ff203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibiotics</topic><topic>Biological diversity</topic><topic>Comparative analysis</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cytokines</topic><topic>Digestive system</topic><topic>Discriminant analysis</topic><topic>Gastroenterology</topic><topic>Gastroenterology & Hepatology</topic><topic>Gastrointestinal system</topic><topic>Gastrointestinal tract</topic><topic>Gut microbiota</topic><topic>Health aspects</topic><topic>Infections</topic><topic>Intestinal microflora</topic><topic>Letter to the Editor</topic><topic>Life Sciences & Biomedicine</topic><topic>Microbiology</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Pneumonia</topic><topic>SARS-CoV-2</topic><topic>Science & Technology</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Systematic review</topic><topic>Tropism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Maio, Flavio</creatorcontrib><creatorcontrib>Ianiro, Gianluca</creatorcontrib><creatorcontrib>Coppola, Gaetano</creatorcontrib><creatorcontrib>Santopaolo, Francesco</creatorcontrib><creatorcontrib>Abbate, Valeria</creatorcontrib><creatorcontrib>Bianco, Delia Mercedes</creatorcontrib><creatorcontrib>Del Zompo, 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Romana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved gut microbiota features after the resolution of SARS-CoV-2 infection</atitle><jtitle>Gut pathogens</jtitle><stitle>GUT PATHOG</stitle><date>2021-10-16</date><risdate>2021</risdate><volume>13</volume><issue>1</issue><spage>1</spage><epage>62</epage><pages>1-62</pages><artnum>62</artnum><issn>1757-4749</issn><eissn>1757-4749</eissn><abstract>Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a tropism for the gastrointestinal tract and several studies have shown an alteration of the gut microbiota in hospitalized infected patients. However, long-term data on microbiota changes after recovery are lacking. Methods We enrolled 30 patients hospitalized for SARS-CoV-2-related pneumonia. Their gut microbiota was analyzed within 48 h from the admission and compared with (1) that of other patients admitted for suspected bacterial pneumonia (control group) (2) that obtained from the same subject 6 months after nasopharyngeal swab negativization. Results Gut microbiota alpha-diversity increased 6 months after the resolution of SARS-CoV-2 infection. Bacteroidetes relative abundance was higher (approximate to 36.8%) in patients with SARS-CoV-2, and declined to 18.7% when SARS-CoV-2 infection resolved (p = 0.004). Conversely, Firmicutes were prevalent (approximate to 75%) in controls and in samples collected after SARS-CoV-2 infection resolution (p = 0.001). Ruminococcaceae, Lachnospiraceae and Blautia increased after SARS-CoV-2 infection resolution, rebalancing the gut microbiota composition. Conclusion SARS-CoV-2 infection is associated with changes in the gut microbiome, which tend to be reversed in long-term period.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>34656179</pmid><doi>10.1186/s13099-021-00459-9</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-6199-6372</orcidid><orcidid>https://orcid.org/0000-0002-9780-7059</orcidid><orcidid>https://orcid.org/0000-0002-5924-6238</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibiotics Biological diversity Comparative analysis Coronaviruses COVID-19 Cytokines Digestive system Discriminant analysis Gastroenterology Gastroenterology & Hepatology Gastrointestinal system Gastrointestinal tract Gut microbiota Health aspects Infections Intestinal microflora Letter to the Editor Life Sciences & Biomedicine Microbiology Microbiomes Microbiota Microbiota (Symbiotic organisms) Pneumonia SARS-CoV-2 Science & Technology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Systematic review Tropism |
| title | Improved gut microbiota features after the resolution of SARS-CoV-2 infection |
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