Andrographolide prevents bone loss via targeting estrogen‐related receptor‐α‐regulated metabolic adaption of osteoclastogenesis

Background and Purpose Metabolic adaptation driven by oestrogen‐related receptor‐α (ERRα/NR3B1) is required to meet the increased energy demand during osteoclast differentiation. Here, we hypothesize that natural product, andrographolide, acts as an ERRα inverse agonist to inhibit osteoclastogenesis...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 2021-11, Vol.178 (21), p.4352-4367
Hauptverfasser:	Huang, Tongling, Fu, Xuekun, Wang, Na, Yang, Meng, Zhang, Minyi, Wang, Binxu, Chen, Tianke, Majaz, Sidra, Wang, Huaiyu, Wong, Chi‐Wai, Liu, Jinsong, Guan, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	andrographolide Animal models Animals Bone Diseases, Metabolic Bone loss Bone marrow Bone resorption Diterpenes energy metabolism ERRalpha Estrogen-Related Receptor ERRα Estrogens Female Glutaminase Glutamine High fat diet Immunoprecipitation Inverse agonists Male Metabolism Mice Mitochondria Natural products Osteoclastogenesis Osteoclasts Osteogenesis Osteopenia Ovariectomy Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Phenylalanine Polymerase chain reaction Receptors, Estrogen - metabolism Site-directed mutagenesis Transcription Factors - metabolism Valine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!