Dose-Dependent Cardioprotective Effect of Hemin in Doxorubicin-Induced Cardiotoxicity Via Nrf-2/HO-1 and TLR-5/NF-κB/TNF-α Signaling Pathways

Doxorubicin (DOX) is one of the most widely used chemotherapeutic drugs, but its cardiotoxicity has been shown to be a dose-restricting factor during therapy. Finding new agents for reducing these complications is still in critical need. The current study aimed to evaluate the possible cardioprotect...

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Veröffentlicht in:	Cardiovascular toxicology 2021-12, Vol.21 (12), p.1033-1044
Hauptverfasser:	Refaie, Marwa M. M., Shehata, Sayed, Ibrahim, Randa Ahmed, Bayoumi, Asmaa M. A., Abdel-Gaber, Seham A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antioxidants Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Cardiology Cardiotoxicity Caspase-3 Complications Disease Models, Animal Doxorubicin GA-binding protein Heart Diseases - chemically induced Heart Diseases - enzymology Heart Diseases - pathology Heart Diseases - prevention & control Heme Oxygenase (Decyclizing) - metabolism Hemin Hemin - pharmacology Inflammation Male Malondialdehyde Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism NF-κB protein Oxidative stress Oxidative Stress - drug effects Pharmacology/Toxicology Rats Rats, Wistar Signal Transduction Toll-Like Receptor 5 - metabolism Toll-like receptors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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