Agomelatine attenuates alcohol craving and withdrawal symptoms by modulating the Notch1 signaling pathway in rats

Alcohol abuse is a significant causative factor of death worldwide. The Notch1 signaling pathway is involved in alcohol tolerance, withdrawal and dependence. Agomelatine is a known antidepressant acting as a melatonin receptor (MT1/2) agonist and a 5-hydroxytryptamine receptor-2C antagonist. However...

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Veröffentlicht in:	Life sciences (1973) 2021-11, Vol.284, p.119904, Article 119904
Hauptverfasser:	Fathi, Doaa, Abulsoud, Ahmed I., Saad, Muhammed A., Nassar, Noha N., Maksimos, Mina M., Rizk, Sherine M., Senousy, Mahmoud A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abuse Acetamides - pharmacology Acetamides - therapeutic use Agomelatine Alcohol craving Alcohol dependence Alcohol use Alcohol withdrawal symptoms Alcoholic beverages Alcoholic Beverages - adverse effects Alcoholism Alcohols Animals Antidepressants Anxiety Anxiety - pathology Behavior, Animal - drug effects Biomarkers - metabolism Brain-derived neurotrophic factor Circadian Rhythm - drug effects Craving Cyclic AMP response element-binding protein Dependence Dopamine Drinking behavior Drug abuse Drug dependence Drug tolerance Gelatinase B Glutamate receptors Hippocampus Hippocampus - metabolism Hydrocortisone Hydrocortisone - blood Male Melatonin Morris Water Maze Test N-Methyl-D-aspartic acid receptors Neuronal Plasticity - drug effects Neurons - drug effects Neurons - metabolism Neurons - pathology Neurotransmitter Agents - blood Notch1 protein Notch1 signaling Open Field Test Open-field behavior Period Circadian Proteins - genetics Period Circadian Proteins - metabolism Rats Rats, Wistar Receptor, Notch1 - metabolism Receptors Serotonin Serum levels Signal transduction Signal Transduction - drug effects Signaling Substance Withdrawal Syndrome - drug therapy Substance Withdrawal Syndrome - metabolism
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