Preparation of Cellulose Hydrogel Dressing with Evenly Dispersed Hydrophobic Drugs by Hydrogen Bonding and Encapsulation Methods

A transparent cellulose‐based functional hydrogel dressing is prepared by hydrogen bonding interaction and encapsulation technique, which can uniformly disperse hydrophobic drugs and has the advantages of simple preparation, good biocompatibility, fast self‐healing ability, and slow drug release. Me...

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Veröffentlicht in:Macromolecular materials and engineering 2021-10, Vol.306 (10), p.n/a
Hauptverfasser: Xu, Juan, Wang, Henan, Jiang, Lihui, Tao, Yiou, Song, Yan, Yu, Shuling, Wang, Ting, Feng, Ningli
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container_issue 10
container_start_page
container_title Macromolecular materials and engineering
container_volume 306
creator Xu, Juan
Wang, Henan
Jiang, Lihui
Tao, Yiou
Song, Yan
Yu, Shuling
Wang, Ting
Feng, Ningli
description A transparent cellulose‐based functional hydrogel dressing is prepared by hydrogen bonding interaction and encapsulation technique, which can uniformly disperse hydrophobic drugs and has the advantages of simple preparation, good biocompatibility, fast self‐healing ability, and slow drug release. Menthol, which is insoluble and irritating, is used as a model drug, encapsulated by ethylenediamine‐modified cyclodextrin, and then loaded onto a hydrogel dressing. The introduction of modified cyclodextrin not only improves the stability and solubility of menthol, but also makes the hydrophobic menthol uniformly dispersed in hydrophilic hydrogel dressing, and the large amount of hydrogen bonding can enable rapid hydrogel generation. In addition, the microstructure, swelling, biocompatibility and drug loading properties of the hydrogel are investigated, and the results show that the hydrogel has good prospects for application in the field of wound dressings. A transparent cellulose‐based functional hydrogel dressing is prepared by hydrogen bonding interactions and encapsulation techniques. Menthol is encapsulated with ethylenediamine‐modified cyclodextrin and then loaded onto the hydrogel dressing. The introduction of modified cyclodextrin not only improves the stability and solubility of menthol, but also makes the hydrophobic menthol uniformly dispersed in the hydrophilic hydrogel dressing.
doi_str_mv 10.1002/mame.202100286
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Menthol, which is insoluble and irritating, is used as a model drug, encapsulated by ethylenediamine‐modified cyclodextrin, and then loaded onto a hydrogel dressing. The introduction of modified cyclodextrin not only improves the stability and solubility of menthol, but also makes the hydrophobic menthol uniformly dispersed in hydrophilic hydrogel dressing, and the large amount of hydrogen bonding can enable rapid hydrogel generation. In addition, the microstructure, swelling, biocompatibility and drug loading properties of the hydrogel are investigated, and the results show that the hydrogel has good prospects for application in the field of wound dressings. A transparent cellulose‐based functional hydrogel dressing is prepared by hydrogen bonding interactions and encapsulation techniques. Menthol is encapsulated with ethylenediamine‐modified cyclodextrin and then loaded onto the hydrogel dressing. 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subjects Biocompatibility
Cellulose
cellulose hydrogels
Chemical bonds
Cyclodextrins
Dispersion
dressings
Drugs
Encapsulation
Ethylenediamine
even dispersion
Hydrogels
Hydrogen bonding
Hydrophobicity
Menthol
protect volatiles
title Preparation of Cellulose Hydrogel Dressing with Evenly Dispersed Hydrophobic Drugs by Hydrogen Bonding and Encapsulation Methods
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