Thermoanalytical studies of a cytotoxic derivative of carbamazepine: iminostilbene
Iminostilbene is an organic compound, being a precursor of some active pharmaceutical ingredients including well-known anti-epileptic drug carbamazepine as well as substance exhibiting toxic properties and posing threat to natural environment itself. Although its derivatives are commonly studied, th...
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| Veröffentlicht in: | Journal of thermal analysis and calorimetry 2021-12, Vol.146 (5), p.2151-2160 |
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| container_title | Journal of thermal analysis and calorimetry |
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| creator | Dołęga, Agnieszka Juszyńska-Gałązka, Ewa Deptuch, Aleksandra Jaworska-Gołąb, Teresa Zieliński, Piotr M. |
| description | Iminostilbene is an organic compound, being a precursor of some active pharmaceutical ingredients including well-known anti-epileptic drug carbamazepine as well as substance exhibiting toxic properties and posing threat to natural environment itself. Although its derivatives are commonly studied, there is a lack of thorough investigation of that compound itself, especially concerning its properties at temperatures close to the melting point. Herein, thermodynamic and structural properties of iminostilbene as well as its vibrational and dynamic properties were studied using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). DSC measurements suggests that in the vicinity of melting point, some enantiotropic transition takes place. TGA measurements reveal that strong sublimation of examined substance is observed at temperatures even tens of degrees lower than melting point. Finally, all measurements indicate that the applied heat treatment induces an irreversible phase transition in the studied sample. |
| doi_str_mv | 10.1007/s10973-020-10410-w |
| format | Article |
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Although its derivatives are commonly studied, there is a lack of thorough investigation of that compound itself, especially concerning its properties at temperatures close to the melting point. Herein, thermodynamic and structural properties of iminostilbene as well as its vibrational and dynamic properties were studied using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). DSC measurements suggests that in the vicinity of melting point, some enantiotropic transition takes place. TGA measurements reveal that strong sublimation of examined substance is observed at temperatures even tens of degrees lower than melting point. Finally, all measurements indicate that the applied heat treatment induces an irreversible phase transition in the studied sample.</description><identifier>ISSN: 1388-6150</identifier><identifier>EISSN: 1588-2926</identifier><identifier>DOI: 10.1007/s10973-020-10410-w</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Analytical Chemistry ; Calorimetry ; Carbamazepine ; Chemistry ; Chemistry and Materials Science ; Differential scanning calorimetry ; Diffraction ; Fourier transforms ; Heat treatment ; Infrared spectroscopy ; Inorganic Chemistry ; Measurement Science and Instrumentation ; Melting points ; Organic compounds ; Phase transitions ; Physical Chemistry ; Polymer Sciences ; Sublimation ; Thermogravimetric analysis ; X ray powder diffraction ; X-rays</subject><ispartof>Journal of thermal analysis and calorimetry, 2021-12, Vol.146 (5), p.2151-2160</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Akadémiai Kiadó, Budapest, Hungary 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-4ca215e54e1fb332d3183cf82ecd91487df5a5f3291b14079bffcd1fb4344dc73</citedby><cites>FETCH-LOGICAL-c420t-4ca215e54e1fb332d3183cf82ecd91487df5a5f3291b14079bffcd1fb4344dc73</cites><orcidid>0000-0002-5570-2478 ; 0000-0002-1808-2775 ; 0000-0001-5599-9673 ; 0000-0002-7451-5563 ; 0000-0002-3964-0721</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10973-020-10410-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10973-020-10410-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Dołęga, Agnieszka</creatorcontrib><creatorcontrib>Juszyńska-Gałązka, Ewa</creatorcontrib><creatorcontrib>Deptuch, Aleksandra</creatorcontrib><creatorcontrib>Jaworska-Gołąb, Teresa</creatorcontrib><creatorcontrib>Zieliński, Piotr M.</creatorcontrib><title>Thermoanalytical studies of a cytotoxic derivative of carbamazepine: iminostilbene</title><title>Journal of thermal analysis and calorimetry</title><addtitle>J Therm Anal Calorim</addtitle><description>Iminostilbene is an organic compound, being a precursor of some active pharmaceutical ingredients including well-known anti-epileptic drug carbamazepine as well as substance exhibiting toxic properties and posing threat to natural environment itself. 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| subjects | Analytical Chemistry Calorimetry Carbamazepine Chemistry Chemistry and Materials Science Differential scanning calorimetry Diffraction Fourier transforms Heat treatment Infrared spectroscopy Inorganic Chemistry Measurement Science and Instrumentation Melting points Organic compounds Phase transitions Physical Chemistry Polymer Sciences Sublimation Thermogravimetric analysis X ray powder diffraction X-rays |
| title | Thermoanalytical studies of a cytotoxic derivative of carbamazepine: iminostilbene |
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