RORα Suppresses Cancer-Associated Inflammation by Repressing Respiratory Complex I-Dependent ROS Generation

Breast cancer development is associated with macrophage infiltration and differentiation in the tumor microenvironment. Our previous study highlights the crucial function of reactive oxygen species (ROS) in enhancing macrophage infiltration during the disruption of mammary tissue polarity. However,...

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Veröffentlicht in:	International journal of molecular sciences 2021-10, Vol.22 (19), p.10665
Hauptverfasser:	Mao, Wei, Xiong, Gaofeng, Wu, Yuanyuan, Wang, Chi, St Clair, Daret, Li, Jia-Da, Xu, Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Breast cancer Cell culture Cell Respiration Chromatin Cytokines Cytokines - metabolism Differentiation Electron transport chain Electron Transport Complex I - metabolism Energy Metabolism Epithelial cells Epithelium Gene expression Gene Expression Regulation, Neoplastic Humans Immunoprecipitation Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Inflammation Mediators - metabolism Macrophages Mammary gland Metastases Mitochondria Neoplasm Metastasis Neoplasm Staging Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Nuclear Receptor Subfamily 1, Group F, Member 1 - metabolism Polarity Reactive oxygen species Reactive Oxygen Species - metabolism Tumor Microenvironment Tumor suppressor genes Tumor-Associated Macrophages - immunology Tumor-Associated Macrophages - metabolism Tumors
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